ArticleOpen veterinary journal2026
Effects of nanocurcumin administration on malondialdehyde and estrogen levels in mice exposed to noise-induced stress.
Article in Open veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: During pregnancy, noise stress has been associated with the activation of the hypothalamic-pituitary-adrenal axis and increased oxidative stress, which can disrupt hormonal balance and adversely affect pregnancy outcomes. Malondialdehyde (MDA) is a key biomarker of lipid peroxidation, whereas estrogen plays a critical role in maintaining gestational homeostasis. Excess oxidative stress and hormonal imbalance may impair fetal development. Nanocurcumin, a curcumin nanoparticle formulation, exhibits enhanced antioxidant and anti-inflammatory properties compared with conventional curcumin and may offer protective effects against pregnancy-related oxidative damage. Aim: This study aimed to evaluate the effects of nanocurcumin on MDA and estrogen levels in pregnant mice exposed to noise-induced stress, contributing to Sustainable Development Goals Methods: An experimental study was conducted using 25 pregnant BALB/c mice randomly divided into five groups: K(-): untreated control, K(+): exposed to 135 dB noise for 40 minutes, P1, P2, and P3: exposed to noise and treated with nanocurcumin at 14, 21, and 24.5 mg/kg body weight, respectively. An electric siren was placed inside a soundproof chamber to deliver noise, and the 135 dB intensity was calibrated using a precision digital decibel meter (Benetech GM1356). Oral treatment was administered from gestational day (GD) 6 to gestational day 18. Serum MDA and estrogen levels were measured using an enzyme-linked immunosorbent assay. Data were analyzed using one-way analysis of variance followed by Tukey's honest significant difference post hoc test ( Results: Noise exposure numerically increased both MDA and estrogen levels, although not all differences reached statistical significance. However, nanocurcumin administration significantly reduced both parameters in a dose-dependent manner. The highest dose (24.5 mg/kg BW, P3 group) resulted in a 40.87% reduction in MDA and a 22.88% reduction in estrogen compared to K(+), with values approaching those in the untreated control. Conclusion: Nanocurcumin has potential as a protective agent against noise-induced oxidative stress and hormonal disturbances during pregnancy. To confirm translational relevance, future research should focus on elucidating underlying molecular mechanisms and evaluating fetal outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.