ArticleOpen veterinary journal2026
The effect of topical and oral combination of ethanolic extract of
Article in Open veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hemorrhoids are a pathological condition characterized by abnormal dilation of blood vessels and swelling in the rectoanal region, often accompanied by inflammation. The ethanolic extract of purple leaf ( Aim: This research aims to assess the potential of topically applied and orally administered purple leaf extract in regulating inflammation in the rectoanal tissue of hemorrhoid-induced rats using 10% Croton oil. Methods: Following a 3-day induction period with 10% Croton oil, the rats were subjected to specific therapeutic regimens for 7 days. Subsequently, the rectoanal tissue was isolated and divided for histopathological analysis and assessment of immunological parameters. tTumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and Transforming Growth Factor Beta 1 (TGF-β1) cytokine levels were quantified using ELISA, while interleukin-10 (IL-10) messenger RNA (mRNA) expression was determined using qRT-PCR. The histopathological observation of the rectoanal and calculation of the rectoanal coefficient were conducted. Results: The application of 10% Croton oil induced a significant elevation of TGF-β1 and TNF-α, but not IL-6, in the negative control group compared to the normal and treated group. The combined topical and oral administration of purple leaf extract reduced TNF-α, IL-6, and TGF-β1 cytokines, and significantly elevated the IL-10 mRNA expression in the rectoanal tissue. However, purple leaf extract did not appear to reduce the rectoanal coefficient. Conclusion: The presence of diverse active compounds, in purple leaf extract notably flavonoids, is thought to modulate tissue inflammation and facilitate tissue repair.
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