Trial reportFrontiers in medicine2026
Effects of dexmedetomidine nasal spray on perioperative anxiety and quality of postoperative recovery in patients undergoing modified radical mastectomy for breast cancer.
Trial report in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: Dexmedetomidine possesses sedative, analgesic, and anxiolytic properties, but there is still a lack of sufficient clinical data regarding its preoperative intranasal administration. The present study was designed to evaluate whether preoperative intranasal dexmedetomidine spray could alleviate perioperative anxiety and improve postoperative recovery quality in patients with breast cancer undergoing modified radical mastectomy. Methods: Ninety patients undergoing modified radical mastectomy were randomly assigned to either the dexmedetomidine group (Group D, Results: The PAS-7 score at 30 min after administration was significantly lower in Group D than in Group C (9.71 ± 2.07 vs. 12.44 ± 1.98, Conclusion: Preoperative intranasal dexmedetomidine spray effectively alleviated preoperative anxiety and improved early postoperative quality of recovery in patients undergoing modified radical mastectomy, without significant adverse effects on intraoperative hemodynamics, although time to emergence was prolonged.
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