ArticleFrontiers in medicine2026
Case Report: Indocyanine green fluorescence imaging in complex focal nodular hyperplasia resection: report of two cases.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This report describes indocyanine green (ICG) fluorescence guidance combined with intraoperative ultrasonography (IOUS) for laparoscopic parenchyma-sparing excision of selected perivascular focal nodular hyperplasia (FNH). In two patients with segment IV lesions abutting the portal vein, preoperative ICG administration (0.5 mg/kg, 24 h prior) enabled real-time intraoperative fluorescence imaging integrated with ultrasonography. The dual-modality navigation provided clear visual contrast, facilitating precise lesion delineation and margin assessment. Both patients underwent successful wedge excision with negative surgical margins, with estimated blood loss of 50-20 mL, respectively. Incidental punctate hyperfluorescent foci were observed on the liver surface; one excised focus showed benign hyperplastic changes on histology, while the clinical significance of the remaining foci remains uncertain. These cases suggest that ICG fluorescence may assist laparoscopic parenchyma-sparing excision of selected perivascular FNH lesions, though further studies are needed to define its reproducibility, limitations, and clinical value.
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