Development of Quorum Sensing Modulators of Streptococcus constellatus.

Keely M Rodriguez, Daniel N Elliott, Ella R Lemieux, Oscar S Liu, Yftah Tal-Gan

Abstract read

In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Keely M RodriguezDepartment of Chemistry, University of Nevada, Reno, Reno, Nevada, USA.ORCID https://orcid.org/0000-0002-5642-4246

Daniel N ElliottDepartment of Chemistry, University of Nevada, Reno, Reno, Nevada, USA.

Ella R LemieuxDepartment of Chemistry, University of Nevada, Reno, Reno, Nevada, USA.

Oscar S LiuDepartment of Chemistry, University of Nevada, Reno, Reno, Nevada, USA.

Yftah Tal-GanDepartment of Chemistry, University of Nevada, Reno, Reno, Nevada, USA.

Funding

National Science Foundation CHE-2316599NIH HHS GM145539

6 · The paper itself

Abstract

Streptococcus constellatus inhabits the healthy human gastrointestinal tract and oral microbiome; however, the incidence of this species becoming opportunistically pathogenic has increased in recent decades. S. constellatus has the potential to cause severe pyogenic infections requiring combination antibiotic therapy or surgical intervention. Some virulence processes in S. constellatus, such as genetic competence, are regulated through quorum sensing (QS), facilitated by its 16-mer competence stimulating peptide (CSP). Several target residues on the CSP molecule were identified that can be mutated to enhance the peptide activity and/or lead to competitive inhibition of the competence regulon QS circuitry, thereby modulating related pathogenic phenotypes. Using a rational design approach, second-generation peptide analog libraries were designed and screened, resulting in optimization of a competitive QS inhibitor, CSP-D1AI4AM6A, with an IC

Indexed as

Anti-Bacterial AgentsBacterial ProteinsPeptidesQuorum SensingHumansAnti-Bacterial AgentsBacterial ProteinsPeptidesautoinducermicrobiologyquorum sensingrational designvirulence

Identifiers

PMID42375126

DOI10.1002/cbic.70444

PMCPMC13316731

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.