ArticleBiomolecules & therapeutics2026
Isoschaftoside Inhibits Osteoclastogenesis by Suppressing the NF-κB and MAPK Pathways.
Article in Biomolecules & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Bone remodeling is regulated by the equilibrium between bone formation and resorption. However, excessive bone resorption by osteoclasts disrupts bone homeostasis and contributes to several bone-related disorders. Hematopoietic lineage cells differentiate into multinucleated osteoclasts through osteoclastogenesis, a process driven by M-CSF and RANKL. Multiple signaling pathways are involved in osteoclast maturation. RANKL-induced activation of NF-κB has been recognized as a crucial mechanism in osteoclast differentiation. Additionally, MAPK signaling activated by RANKL plays a significant role in this process. The stimulation of NF-κB and MAPK by RANKL enhances the transcription of numerous genes associated with osteoclastogenesis. Isoschaftoside (ISH), a C-glycosyl flavonoid, can be isolated from
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