Evidence map›Paper›PMID 42374974›Full record

ArticleAlcohol, clinical & experimental research2026

Patterns, Predictors, and Correlates of Problematic Alcohol Use and Remission From Adolescence to Early Midlife.

Megan E Cooke, Erin Lumpe, Mallory Stephenson, Sally I-Chun Kuo, Peter B Barr, Sarah J Brislin, Holly Poore, Fazil Aliev, Maarit Piirtola, Antti Latvala and 5 more

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcohol, clinical & experimental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Megan E CookeDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.ORCID https://orcid.org/0000-0001-9405-367X
Erin LumpeDepartment of Psychology, Rutgers University, Piscataway, New Jersey, USA.
Mallory StephensonVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0002-1498-4333
Sally I-Chun KuoDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.ORCID https://orcid.org/0000-0002-6192-1001
Peter B BarrDepartment of Psychiatry & Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, New York, New York, USA.ORCID https://orcid.org/0000-0001-9321-657X
Sarah J BrislinDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.ORCID https://orcid.org/0000-0003-4303-8124
Holly PooreDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.ORCID https://orcid.org/0000-0003-0235-6070
Fazil AlievDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
Maarit PiirtolaInstitute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.
Antti LatvalaInstitute of Criminology and Legal Policy, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0001-5695-117X
Jill A RabinowitzDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
Richard J RoseDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA.
Jaakko KaprioInstitute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.
Danielle M DickDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.ORCID https://orcid.org/0000-0002-1636-893X
Jessica E SalvatoreDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.ORCID https://orcid.org/0000-0001-5504-5087

Funding

The development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6M
Twin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3M
Genetics, Romantic Relationships, and Alcohol Misuse in Emerging AdulthoodK01AA024152 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI SALVATORE, JESSICA E · 2016 to 2020
$741k
Neural, genetic, and environmental indicators of treatment outcomes for adolescent substance useK23DA058808 · NIDA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Sarah Brislin · 2024 to 2026
$542k
NIAAA NIH HHS K01 AA024152NIAAA NIH HHS K01AA024152NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K02AA018755NIAAA NIH HHS R01 AA015416NIAAA NIH HHS R01AA015416NIDA NIH HHS K23 DA058808NIDA NIH HHS K23DA058808Research Council of Finland 100499Research Council of Finland 118555Research Council of Finland 141054Research Council of Finland 205585Research Council of Finland 263278Research Council of Finland 264146Research Council of Finland 265240Research Council of Finland 308248Research Council of Finland 312073Research Council of Finland 352792
6 · The paper itself

Abstract

backgroundThe goal of this paper is to identify environmental, behavioral, and genetic predictors and early midlife correlates of problematic alcohol Use (PAU) patterns from adolescence to early midlife.

methodsThe data are from 1463 twin individuals (60.5% female) in the population-based FinnTwin12 cohort born 1983-1987. PAU was assessed at ages 14, 22 and 37 using symptoms of alcohol use disorder (AUD) obtained from psychiatric interviews, mmMAST scores, and the AUDIT. Self-reported health and well-being were assessed at age 37. A behavioral and environmental risk index (BERI) was created by summing six risk factors: low socioeconomic status in childhood, family history of AUD, childhood externalizing and internalizing behaviors, adolescent substance use, peer substance use, and stressful life events in adolescence. The twins' genetic predispositions were indexed using polygenic scores for externalizing behavior (PGS

resultsTwins were classified into four PAU groups: Never (n = 599, reference), Remitted (n = 480), Persistent (n = 271), and Late-onset (n = 113). When included in the same model, both BERI and PGS

conclusionsPersistent PAU was associated with the most negative outcomes in early midlife, and childhood and adolescent risk factors and genetic risk as indexed by PGS

Indexed as

Alcohol DrinkingAlcoholismAdolescentAdultCohort StudiesFemaleFinlandGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMaleRisk FactorsYoung Adultearly midlifeenvironmental risklate‐onsetpersistentpolygenic scoreproblem alcohol useremitted

Identifiers

PMID42374974
PMCPMC13316461

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.