Evidence map›Paper›PMID 42374907›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Nickel-Catalyzed 1,2-Arylalkenylation of Unactivated Alkenes Enabled by a Native Hydroxy Group.

Dongping Wang, Guozhi Zhao, Yanke He, Fengjiao Wang, Yuxin Zhang, Shanshan Wei, Zhenhua Jia, Xuefei Zhao, Peng Wang, Teck-Peng Loh

Abstract read
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Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Dongping WangHenan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou, P.R. China.ORCID https://orcid.org/0009-0003-9481-2164
Guozhi ZhaoHenan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou, P.R. China.
Yanke HeHenan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou, P.R. China.
Fengjiao WangHenan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou, P.R. China.
Yuxin ZhangHenan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou, P.R. China.
Shanshan WeiHenan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou, P.R. China.
Zhenhua JiaHenan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou, P.R. China.
Xuefei ZhaoInstitute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, P.R. China.ORCID https://orcid.org/0000-0003-2314-1431
Peng WangState Key Laboratory of Organometallic Chemistry and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai, P.R. China.ORCID https://orcid.org/0000-0002-6442-3008
Teck-Peng LohHenan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou, P.R. China.

Funding

Agency for Science, Technology, and Research (A*STAR)Distinguished University Professor grant (Nanyang Technological UniversityMTC Individual Research Grant M21K2c0114National Natural Science Foundation of China 22371293National Natural Science Foundation of China 22401081National Natural Science Foundation of China 22501290Program of Shanghai Academic/Technology Research Leader 23XD1424500RIE2025 MTC Programmatic Fund M22K9b0049the Start-up Grant of Henan University of Technology 2023BS007the Start-up Grant of Henan University of Technology 2024PYJH064
6 · The paper itself

Abstract

Transition-metal-catalyzed dicarbofunctionalization of alkenes represents a powerful strategy for building molecular complexity in a single step. Here we report an unprecedented nickel-catalyzed 1,2-arylalkenylation of unactivated alkenyl alcohols using alkenyl boronates and aryl iodides. This method uniquely leverages the native hydroxyl group as an intrinsic directing handle, eliminating the need for pre-installed auxiliaries and streamlining the synthesis of structurally diverse alkenol derivatives. The reaction proceeds under mild conditions with broad functional group tolerance and excellent regioselectivity, enabling efficient construction of valuable building blocks. Mechanistic studies, supported by DFT calculations, reveal a Ni(0)/Ni(I)/Ni(II) catalytic cycle probably involving aryl radical intermediates. By exploiting alcohols as directing groups, this work expands the scope of alkene dicarbofunctionalization and provides a versatile platform for late-stage functionalization relevant to pharmaceuticals, agrochemicals, and materials development.

Indexed as

1,2‐arylalkenylationalkenyl alcoholsnative hydroxyl groupnickel‐catalyzedunactivated alkenes

Identifiers

PMID42374907
PMCPMC13528529

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.