Evidence map›Paper›PMID 42374852›Full record

ArticleMolecular plant pathology2026

Imprecise Cas12a/ssODN-Mediated Editing of eIF4E1 Confers Dominant-Negative Resistance to Potato Virus Y in Solanum tuberosum.

Alessandra Lucioli, Raffaela Tavazza, Attila Molnar, Vincenza Ilardi, Adéla Přibylová, Mario Tavazza

Abstract read
In one paragraph

Article in Molecular plant pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alessandra LucioliDivision Biotechnologies, ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Casaccia Research Center, Rome, Italy.ORCID 0000-0003-1012-5547
Raffaela TavazzaDivision Biotechnologies, ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Casaccia Research Center, Rome, Italy.ORCID 0000-0002-9064-0495
Attila MolnarInstitute of Molecular Plant Sciences, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-1044-6327
Vincenza IlardiResearch Centre for Plant Protection and Certification (CREA-DC), Council for Agricultural Research and Economics (CREA), Rome, Italy.ORCID 0000-0003-3657-1158
Adéla PřibylováDepartment of Experimental Plant Biology, Faculty of Science, Charles University, Prague, Czech Republic.ORCID 0000-0001-8675-5065
Mario TavazzaDivision Biotechnologies, ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Casaccia Research Center, Rome, Italy.ORCID 0000-0002-7942-1064

Funding

ERDF Programme Johannes Amos Comenius CZ.02.01.01/00/22_008/0004581Ministry of Education, Youth and Sports of the Czech Republic ID:90254
6 · The paper itself

Abstract

Mutants in the eukaryotic initiation factor 4E (eIF4E) gene family provide recessive resistance to plant viruses. Previously, we demonstrated that knocking out SteIF4E1 potato alleles (A, B, B, B1) resulted in limited resistance to a necrogenic PVY isolate (NTN). Expanding on this, we used a non-transgenic method employing Cas12a and a single-stranded oligodeoxynucleotide (ssODN) as a repair template to introduce amino acid changes in SteIF4E1, attempting to mimic the Capsicum PVY resistance allele pvr2

Indexed as

Disease ResistanceEukaryotic Initiation Factor-4EPlant DiseasesPlant ProteinsPotyvirusSolanum tuberosumBase SequenceMutationPlants, Genetically ModifiedEukaryotic Initiation Factor-4EPlant Proteins

Identifiers

PMID42374852
PMCPMC13315812

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.