Evidence map›Paper›PMID 42374771›Full record

ArticleJournal of women's health (2002)2026

Patterns of Antibiotic Utilization and Bacterial Susceptibility of Prenatal Urinary Tract Infections.

Paige D Wartko, Sharon Fuller, Lisa Bastarache, Susan M Shortreed, Katelin B Nickel, Michael J Durkin, Sarah S Osmundson, Sandra McAteer, Anne M Butler, Sascha Dublin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of women's health (2002), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Paige D WartkoKaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.ORCID 0000-0003-0087-3429
Sharon FullerKaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
Lisa BastaracheDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Susan M ShortreedKaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
Katelin B NickelDivision of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Michael J DurkinDivision of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Sarah S OsmundsonDepartment of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sandra McAteerDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
Anne M ButlerDivision of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.
Sascha DublinKaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.

Funding

Identifying Optimal Antibiotic Regimens to Treat Urinary Tract Infections During PregnancyR01HD107083 · NICHD · WASHINGTON UNIVERSITY · PI Anne Mobley Butler · 2022 to 2026
$3.4M
NICHD NIH HHS R01 HD107083
6 · The paper itself

Abstract

backgroundChoosing antibiotics for prenatal urinary tract infections (UTIs) is challenging because fetal safety data are inconclusive and must be weighed against resistance. Recent information on prescribing patterns and antimicrobial susceptibility is sparse; we aimed to address this gap. STUDY

designWe used electronic health record data from two US health systems (Kaiser Permanente Washington [KPWA] and Vanderbilt University Medical Center [VUMC]) to ascertain pregnancies from January 1, 2006, to August 31, 2023, to individuals aged 15-49. We included outpatient-treated prenatal UTIs with an oral UTI antibiotic plus a diagnosis or positive urine culture. We described patterns of antibiotic utilization and susceptibility overall (2006-2023) and by year (2010-2022).

resultsWe identified 10,734 eligible UTIs. The most common antibiotics were nitrofurantoin (KPWA: 42%; VUMC: 65%) and first generation cephalosporins (KPWA: 23%; VUMC: 15%). Nitrofurantoin decreased substantially from 2010 to 2022 (KPWA: from 50% to 27%; VUMC: 65-49%), while first generation cephalosporins increased (KPWA: 12 to 45%; VUMC: 14 to 21%).

conclusionsIn two health systems in different regions, nitrofurantoin decreased substantially while first generation cephalosporins increased, despite better nitrofurantoin susceptibility. Other concerns, like malformation risk, may have influenced prescribing. Further research and guideline development are needed to weigh risks versus benefits of different antibiotics for prenatal UTIs.

Indexed as

Anti-Bacterial AgentsPractice Patterns, Physicians'Pregnancy Complications, InfectiousUrinary Tract InfectionsAdolescentAdultAnti-Infective Agents, UrinaryElectronic Health RecordsFemaleFirst Generation CephalosporinsHumansMicrobial Sensitivity TestsMiddle AgedNitrofurantoinPregnancyThird Generation CephalosporinsAnti-Bacterial AgentsAnti-Infective Agents, UrinaryFirst Generation CephalosporinsNitrofurantoinThird Generation Cephalosporinsantibiotic resistanceantibioticsantimicrobial susceptibilityelectronic health record datapregnancyurinary tract infection

Identifiers

PMID42374771
PMCPMC13641723

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.