Evidence map›Paper›PMID 42374739›Full record

ArticlePlant communications2026

3D mesoporous graphene nanoparticle-mediated transient silencing of susceptibility genes confers broad-spectrum disease resistance in crops.

Wangshan Lu, Yule Ye, Chao Wang, Yizhou Hao, Zhaojie Chen, Zhuoyi Lin, Jinbiao Ma, Yueyi Ren, Xinyu Liu, Dongong Niu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wangshan LuState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China.
Yule YeState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China.
Chao WangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China.
Yizhou HaoGuangzhou Moxi Technology Co Ltd., Guangzhou 510535, China.
Zhaojie ChenGuangxi Key Laboratory of Agric-Environment and Agric-Products Safety, College of Agriculture, Guangxi University, Nanning 530004, Guangxi, China.
Zhuoyi LinGuangxi Key Laboratory of Agric-Environment and Agric-Products Safety, College of Agriculture, Guangxi University, Nanning 530004, Guangxi, China.
Jinbiao MaState Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China.
Yueyi RenState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China.
Xinyu LiuState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China.
Dongong NiuState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China.
Zhengguang ZhangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China.
Jianhao ChenInternational Center for Quantum Materials, School of Physics, Peking University, Beijing 100871, China. Electronic address: chenjianhao@pku.edu.cn.
Gan AiState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China. Electronic address: ganai@njau.edu.cn.
Daolong DouState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China. Electronic address: ddou@njau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene editing of plant susceptibility (S) genes can enhance crop disease resistance, but permanent disruption of these genes often causes undesirable side effects, including reduced growth and yield. Here, we developed three-dimensional mesoporous graphene nanoparticles (MGNs) for the protection and delivery of double-stranded RNA (dsRNA) into plant cells, enabling transient silencing of S genes. MGNs showed high colloidal stability, strong dsRNA-binding affinity, and effective protection of dsRNA against UV exposure, RNase degradation, and heat. In Nicotiana benthamiana, MGN-dsRNA treatment achieved up to 78% target-gene silencing and significantly enhanced resistance to Phytophthora capsici without growth penalties when applied at optimized intervals. In rice, transient silencing of the S gene ROD1 using MGN-dsRNA conferred broad-spectrum resistance to both Magnaporthe oryzae and Xanthomonas oryzae pv. oryzae in growth-chamber and field trials, while also increasing yield relative to controls. This nanoparticle-enabled transient gene-silencing strategy provides a rapid, non-transgenic approach for improving crop disease resistance and may help avoid the trade-offs associated with permanent S-gene modification.

Indexed as

Crops, AgriculturalDisease ResistanceGene SilencingGraphiteNanoparticlesOryzaPlant DiseasesMagnaportheNicotianaPhytophthoraRNA, Double-StrandedXanthomonasGraphiteRNA, Double-Strandedbroad-spectrum resistancemesoporous grapheneRNAisusceptibility genes

Identifiers

PMID42374739
PMCPMC13589569

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.