Evidence map›Paper›PMID 42374533›Full record

ArticleJournal of animal science and biotechnology2026

Rotavirus infection induces ferroptosis through NCOA4-mediated ferritinophagy in IPEC-J2 cells.

Ye Zhao, Xia Dong, Qingyuan Lan, Luqian She, Yongsheng Hu, Lei Chen, Mailin Gan, Lili Niu, Yan Wang, Xiaofeng Zhou and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ye Zhao *State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, No. 211, Huimin Road, Wenjiang District, Chengdu City, 611130, China.
Xia Dong *State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, No. 211, Huimin Road, Wenjiang District, Chengdu City, 611130, China.
Qingyuan LanState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, No. 211, Huimin Road, Wenjiang District, Chengdu City, 611130, China.
Luqian SheState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, No. 211, Huimin Road, Wenjiang District, Chengdu City, 611130, China.
Yongsheng HuState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, No. 211, Huimin Road, Wenjiang District, Chengdu City, 611130, China.
Lei ChenState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, No. 211, Huimin Road, Wenjiang District, Chengdu City, 611130, China.
Mailin GanState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, No. 211, Huimin Road, Wenjiang District, Chengdu City, 611130, China.
Lili NiuState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, No. 211, Huimin Road, Wenjiang District, Chengdu City, 611130, China.
Yan WangState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, No. 211, Huimin Road, Wenjiang District, Chengdu City, 611130, China.
Xiaofeng ZhouState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, No. 211, Huimin Road, Wenjiang District, Chengdu City, 611130, China.
Linyuan ShenState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, No. 211, Huimin Road, Wenjiang District, Chengdu City, 611130, China. shenlinyuan@sicau.edu.cn.
Li ZhuState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, No. 211, Huimin Road, Wenjiang District, Chengdu City, 611130, China. zhuli@sicau.edu.cn.

Funding

China Agriculture Research System CARS-35ig Industry Technology System Innovation Team of Sichuan Province SCCXTD-2025-8National Key R&D Program of China 2024YFF1001500Sichuan Science and Technology Program 2022YFN0048，2021YFYZ0007, 2021YFYZ0030
6 · The paper itself

Abstract

backgroundRotavirus (RV) infection damages mature intestinal epithelial cells and is a leading cause of severe diarrhea in infants and young animals. However, the host cell death pathways involved in RV infection remain incompletely understood. This study used an RV-infected IPEC-J2 cell model and integrated transcriptomic, proteomic, and functional assays to investigate whether RV infection is associated with ferroptosis and NCOA4-mediated ferritinophagy.

resultsHigh-throughput sequencing and data-independent acquisition (DIA)-based quantitative proteomic analysis showed enrichment of ferroptosis, autophagy, and cell death-related signaling pathways after RV infection. Functional assays showed that RV infection was associated with intracellular Fe

conclusionsThese findings support a model in which RV infection promotes ferroptosis-associated changes and VP6 expression through NCOA4-mediated ferritinophagy in IPEC-J2 cells. As this study was performed in vitro and did not directly measure epithelial transport, barrier function, infectious viral yield, or diarrheal outcomes, further in vivo studies are needed to determine the contribution of this pathway to RV pathogenesis.

Indexed as

FerritinophagyFerroptosisIPEC-J2 cellNCOA4Rotavirus

Identifiers

PMID42374533
PMCPMC13317329

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.