Evidence map›Paper›PMID 42374500›Full record

ArticleMicrobiome2026

IL-17A deficiency in HLA-DR3 transgenic mice enriches beneficial Prevotella species in gut to promote Tregs and reduce CNS autoimmunity.

Shailesh K Shahi, Sudeep Ghimire, Samantha N Jensen, Peter C Lehman, Allison G Rux, Souradip Sinha, Nicholas Borcherding, Munir R Tanas, Katherine N Gibson-Corley, Sukirth M Ganesan and 2 more

Abstract read
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In one paragraph

Article in Microbiome, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shailesh K Shahi *Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, USA.
Sudeep Ghimire *Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, USA.
Samantha N JensenDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, USA.
Peter C LehmanDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, USA.
Allison G RuxDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, USA.
Souradip SinhaDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, USA.
Nicholas BorcherdingDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Munir R TanasDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, USA.
Katherine N Gibson-CorleyDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, USA.
Sukirth M GanesanMolecular Medicine Graduate Program, University of Iowa, Iowa City, USA.
Nitin J KarandikarDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, USA.
Ashutosh K MangalamDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, USA. ashutosh-mangalam@uiowa.edu.ORCID 0000-0002-9926-2531

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
PREDOCTORAL TRAINING PROGRAM IN IMMUNOLOGYT32AI007485 · NIAID · UNIVERSITY OF IOWA · PI Kevin L Legge · 1995 to 2026
$5.4M
Linking diet, gut microbiota and autoimmune disease: Bacteria induced phytoestrogen metabolites impact immune function in Experimental Autoimmune EncephalitisR01AI137075 · NIAID · UNIVERSITY OF IOWA · PI MANGALAM, ASHUTOSH KUMAR · 2018 to 2022
$2.0M
BLRD VA I01 BX006112CSRD VA I01 CX002212National Institutes of Health/NIAID R01AI137075NIAID NIH HHS R01 AI137075NIAID NIH HHS T32 AI007485NIEHS NIH HHS P30 ES005605Veteran Affairs Merit Award 1I01CX002212
6 · The paper itself

Abstract

backgroundHuman Leukocyte Antigen (HLA) class-II genes, particularly HLA-DR2 and HLA-DR3, and the gut microbiota are intricately linked to the pathobiology of multiple sclerosis (MS) through their ability to regulate host immunity, a critical factor in disease pathogenesis. An imbalance between anti-inflammatory CD4

resultsUtilizing IL-17A-deficient (DR3.IL-17A

conclusionsThis study redefines IL-17A's role in immune regulation, emphasizing its ability to directly influence gut microbiota composition and the abundance of Treg-promoting bacteria. Thus, gut microbiota-targeted therapies, particularly those promoting Treg-inducing bacteria like Prevotella species, hold promise for treating autoimmune diseases by modulating host immune responses. Video Abstract.

Indexed as

AutoimmunityCentral Nervous SystemGastrointestinal MicrobiomeHLA-DR3 AntigenInterleukin-17PrevotellaT-Lymphocytes, RegulatoryAnimalsEncephalomyelitis, Autoimmune, ExperimentalHumansInterleukin-10MiceMice, KnockoutMice, TransgenicMultiple SclerosisTh17 CellsHLA-DR3 AntigenIl17a protein, mouseInterleukin-10Interleukin-17Experimental Autoimmune Encephalomyelitis (EAE)Gut microbiotaIL-17AImmune regulationMultiple sclerosisPrevotellaTregs

Identifiers

PMID42374500
PMCPMC13326294

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.