ArticleBMC sports science, medicine & rehabilitation2026
The effect of preoperative rehabilitation exercises on postoperative bone mineral density, tendon-bone healing, and physical function after anterior cruciate ligament reconstruction: a multi-center randomized controlled clinical trial.
Article in BMC sports science, medicine & rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05924178 (A Study on the Effect of Exercise Rehabilitation on Bone Mineral Density, Reconstruction Ligament Tendon Bone Healing and Cartilage After ACL Rupture and Patellar Dislocation), which is not on this map. Not yet cited in PubMed.
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A Study on the Effect of Exercise Rehabilitation on Bone Mineral Density, Reconstruction Ligament Tendon Bone Healing and Cartilage After ACL Rupture and Patellar Dislocation
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6 authors.
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Abstract
purposeThe impact of preoperative rehabilitation on bone mineral density (BMD) and tendon-bone healing in anterior cruciate ligament reconstruction (ACLR) patients is unknown.
methodsA total of 53 ACL rupture patients were randomized into 2 groups (Control Group [CON, n = 27] and Exercise rehabilitation group [ER, n = 26]). The CON received conventional treatment, and the ER group received 6-week exercise on this basis. Subsequently, both groups underwent ACLR. At baseline, after 3, 6 and 12 months post-ACLR, the knee BMD, magnetic resonance imaging, and physical function were measured.
resultsThe BMD of lateral femur condyle (LFC) in ER group was higher than CON group at 3 and 6 months post-ACLR (p = 0.004, 0.01). The signal/noise quotient (SNQ) of proximal and distal segments in ER group were lower than CON group at 6 and 12 months post-ACLR (p = 0.02, 0.03). The medial femoral condyle cartilage thickness in ER group was begun thicker than CON group at 3 months post-ACLR (p = 0.04). At 6 months post-ACLR, the relative peak torque of the quads and hamstrings, the balance composite score, the Lysholm and IKDC scores in the ER group were better than CON group (Quads p = 0.02; Hamstrings p = 0.01; balance p < 0.001; Lysholm p < 0.001; IKDC p < 0.001). The difference value of BMD from baseline to 3 months post-ACLR in medial femoral condyles (MFC) exhibited positive correlations with 6 and 12 months post-ACLR within distal autograft SNQ (p = 0.025; 0.011).
conclusionACLR patients who undergo preoperative rehabilitation can effectively delay the decline of BMD in the LFC, enhance the tendon-bone healing, improve the knee articular cartilage thickness and advance the physical function. The less the early BMD of MFC loss in early postoperative, the better the later tendon-bone healing within or near the tibial tunnel.
trial registrationPRS, NCT05924178. Registered 28 May 2023, www. CLINICALTRIALS: gov .
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