Evidence map›Paper›PMID 42374458›Full record

ArticleJournal of nanobiotechnology2026

Self-supplying hydrogen peroxide-driven gold nanoparticle aggregation via bio-orthogonal click reaction activates cGAS-STING-PERK pathway for multimodal tumor therapy.

Junyou Li, Kaiqi Hu, Man Lung Lee, Ting Li, Pinyou Chen, Chengke Wang, Hung-Wing Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Junyou LiDepartment of Chemistry, The Chinese University of Hong Kong, New Territories, 000000, Hong Kong, China.
Kaiqi HuDepartment of Chemistry, The Chinese University of Hong Kong, New Territories, 000000, Hong Kong, China.
Man Lung LeeDepartment of Chemistry, The Chinese University of Hong Kong, New Territories, 000000, Hong Kong, China.
Ting LiDepartment of Chemistry, The Chinese University of Hong Kong, New Territories, 000000, Hong Kong, China.
Pinyou ChenDepartment of Chemistry, The Chinese University of Hong Kong, New Territories, 000000, Hong Kong, China.
Chengke WangDepartment of Food Science, Ludong University, Yantai, 264000, Shan Dong Province, China. chengkewang@163.com.
Hung-Wing LiDepartment of Chemistry, The Chinese University of Hong Kong, New Territories, 000000, Hong Kong, China. hungwingli@cuhk.edu.hk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We developed an effective nanoplatform,

Indexed as

GoldHydrogen PeroxideMetal NanoparticlesAnimalsCell Line, TumorcGAS-STING Signaling PathwayCombined Modality TherapyCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHumansMembrane ProteinsMiceNucleotidyltransferasesPhotochemotherapySTING ProteinTumor MicroenvironmentCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseGoldHydrogen PeroxideMembrane ProteinsNucleotidyltransferasesSTING ProteinBio-orthogonal tetrazole/alkene cycloadditionEndoplasmic reticulum stressFenton-like reactionMitochondria targetingSelf-supplying H2O2Type I photodynamic therapy

Identifiers

PMID42374458
PMCPMC13576277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.