ArticleJournal of nanobiotechnology2026
Metal-organic framework-based fuel-driven chemical reaction network for ferroptosis therapy.
Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Ferroptosis is a prospective approach for cancer treatment. However, the efficacy of ferroptosis therapy is limited by three parallel ferroptosis defense pathways: the glutathione (GSH)-glutathione peroxidase 4 (GPX4) pathway, the ferroptosis suppressor protein 1 (FSP1)-ubiquinol (CoQH2) pathway, and the dihydroorotate dehydrogenase (DHODH)-CoQH2 pathway. Inspired by the principles of preprogrammed chemical reaction networks (CRNs), herein, a novel drug delivery system (SRF@Au@M NPs) was designed based on MIL-100(Fe) for predictable behaviors in tumor cells to break the three ferroptosis defense systems. SRF@Au@M NPs were fabricated through the size optimization of MIL-100(Fe), sorafenib (SRF) loading, in-situ growth of Au nanoparticles (Au NPs) and surface modification with dihydrolipoic acid derivatives. SRF@Au@M NPs disintegrate in the presence of high concentrations of GSH, releasing sorafenib (SRF) into tumor cells, which reduces GSH synthesis and inhibits GPX4 activity. The Au nanoparticles decompose glucose to produce H
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