Evidence map›Paper›PMID 42374383›Full record

Trial reportBMC oral health2026

Extended platelet rich fibrin versus allograft as a space filling material in immediate dental implant placement.

Hala Mohammed Mohammed Ahmed Elnaggar, Nesma El-Gohary, Ayman Ahmed Mustafa Yaseen, Mohamed Abdel-Moniem Tawfik

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
In one paragraph

Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07445776 (Extended Platelet Rich Fibrin Versus Allograft as Space Filling Material in Immediate Dental Implant Placement), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07445776 nacompletednot on this map

Extended Platelet Rich Fibrin Versus Allograft as Space Filling Material in Immediate Dental Implant Placement

TypeinterventionalSponsorMansoura UniversityRan2024 to 2025Enrolled28ConditionsImmediate Implant Placement, Gap Filling With e-PRF, Gap Filling With AllograftArmsAllograft, e-PRF
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hala Mohammed Mohammed Ahmed ElnaggarDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mansoura University, Mansoura, Egypt. halaelnaggar93@mans.edu.eg.ORCID 0000-0002-6849-8736
Nesma El-GoharyDepartment of Fixed Prosthodontics, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.ORCID 0000-0001-6966-6888
Ayman Ahmed Mustafa YaseenDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.ORCID 0000-0003-3420-459X
Mohamed Abdel-Moniem TawfikDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.ORCID 0000-0001-7897-5535

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmediate implant has been one of the solutions to decrease bone resorption after tooth extraction. Gap distance between the dental implant and adjacent bone has undergone much research to enhance bone formation in this area. This is small exploratory study that aimed to compare the efficacy of extended platelet rich fibrin (e-PRF) a regenerative biomaterial produced by heating platelet-poor plasma (PPP) to denature albumin, extending the resorption time of standard PRF from 2 to 3 weeks to 4-6 months, as well as allograft as a space filling material in immediate dental implant placement. PATIENTS AND

methodsTwenty-eight implants were placed for the prosthetic replacement of non-restorable single-rooted maxillary teeth using immediate implant placement. Patients were randomly allocated into two equal groups (n = 14 each). In Group I, allograft was placed in the peri-implant gap, whereas in Group II, e-PRF was used. Implant stability was assessed using resonance frequency analysis (RFA). Buccal bone thickness and marginal bone loss were evaluated using CBCT throughout the follow-up period. Statistical analysis was performed on all clinical and radiographic data.

resultsA total of 28 patients received 28 immediate implants in the maxillary esthetic zone. During the 12-month follow-up period, all implants were successful with no complications. No statistically significant differences were observed between the groups regarding implant stability, marginal bone loss, or buccal bone thickness.

conclusionWithin this small exploratory trial, no statistically significant intergroup differences were detected between e-PRF and allograft as space-filling materials around immediate implants regarding stability, marginal bone loss, and buccal bone thickness.

trial registrationClinical-Trials.gov PRS ( https://register. CLINICALTRIALS: gov ) has this study registered under the identifier number. NCT07445776 on 03/02/2026.

Indexed as

AllograftsDental Implantation, EndosseousDental Implants, Single-ToothImmediate Dental Implant LoadingPlatelet-Rich FibrinAdultAlveolar Bone LossCone-Beam Computed TomographyFemaleHumansMaleMaxillaMiddle AgedAllografte-PRFImmediate implantImplant stabilitySpace filling, Gap filling

Identifiers

PMID42374383
PMCPMC13312693

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.