SynthesisBMC nephrology2026
Multiparametric functional MRI for detection of early renal allograft dysfunction after kidney transplantation: a systematic review and meta-analysis.
Synthesis in BMC nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Texture Analysis of Multiparametric Kidney MRI-A Non-Invasive Approach to Chronic Kidney Disease State.Biomedicines · 2026Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundKidney transplantation is the gold-standard renal-replacement therapy for end-stage kidney disease, yet delayed graft function affects 5-50% of recipients and predicts chronic allograft dysfunction. Functional magnetic resonance imaging (fMRI) offers a non-invasive means to simultaneously assess allograft perfusion, oxygenation, and microstructure.
methodsWe systematically searched PubMed, Web of Science, Cochrane Library, Embase, and MEDLINE for studies evaluating arterial spin labeling (ASL), blood oxygen level-dependent (BOLD), diffusion-weighted imaging (DWI), and intravoxel incoherent motion (IVIM) MRI in kidney transplant recipients. Study quality was appraised with QUADAS-2. Data were pooled using random-effects models, with subgroup analyses by magnetic field strength, post-transplant time, and baseline creatinine.
resultsTwenty-eight studies comprising 1,956 recipients were included. ASL-derived cortical renal blood flow (RBF) discriminated normal from impaired renal function (estimated glomerular filtration rate (eGFR) ≥ 60 vs. <60 mL/min/1.73 m²; mean difference (MD) 98.48mL·min⁻¹·100 g⁻¹, 95% confidence interval (CI) 68.66-128.31; P < 0.00001; I²=57%) and correlated with eGFR (r = 0.58). BOLD identified acute rejection (lower R2*; I²=77-86%) but not acute tubular necrosis. IVIM-derived D values showed the strongest discriminatory power (MD 0.14-0.16 × 10⁻³ mm²/s; P < 0.00001; I²=0%). Substantial heterogeneity (I²=18-98%) limited conclusions for some parameters.
conclusionsMultiparametric fMRI, particularly ASL and IVIM shows promise for detecting early allograft dysfunction. However, marked inter-study heterogeneity underscores the need for standardized protocols before clinical implementation.
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