Targeting the crosstalk between Alzheimer's disease and gastrointestinal cancers.

Rui Gong, Hao Wang, Lei Cao, Haijing Niu, Axel Rominger, Zhongguang Luo, Ruiqing Ni

Abstract readReview

In one paragraph

Review in Molecular medicine (Cambridge, Mass.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rui GongDepartment of Digestive Disease, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Hao WangHepatobiliary Surgery, Department of General Surgery, Huashan Hospital & Cancer Metastasis Institute, Fudan University, Shanghai, 200040, China.

Lei CaoDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, 3010, Switzerland.

Haijing NiuState Key Laboratory of Cognitive Neuroscience and Learning &IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China.

Axel RomingerDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, 3010, Switzerland.

Zhongguang LuoDepartment of Digestive Disease, Huashan Hospital, Fudan University, Shanghai, 200040, China. luozg@fudan.edu.cn.

Ruiqing NiDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, 3010, Switzerland. ruiqing.ni@unibe.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidemiological studies have revealed an inverse association between Alzheimer's disease and cancer. Here, we discuss the mechanisms involved in the relationship between Alzheimer's disease and gastrointestinal cancers, particularly pancreatic and gastric-colorectal cancers. The gut‒brain axis and pancreas‒brain axis connect the central nervous system with peripheral organs and form immune‒metabolic networks. We focus on bidirectional tumor-brain communication, involving cell-death pathways, apoptosis, metabolic dysregulation, microbiota, metabolic dysregulation, neuroinflammation, immune system and sensory-sympathetic circuits, and neural remodeling. Furthermore, we discuss potential integrated, multitarget therapeutic strategies, including metabolic regulation, microbiome interventions, and immune modulation. Prospective longitudinal cohorts incorporating prediagnostic exposures and molecular pathology are needed to establish temporality.

Indexed as

Alzheimer DiseaseGastrointestinal NeoplasmsAnimalsBrainHumansAlzheimer's diseaseGastrointestinal cancerGut‒brain axisOrgan‒organ communicationPancreas‒brain axisPancreatic cancer

Identifiers

PMID42374181

DOI10.1186/s10020-026-01545-x

PMCPMC13579870

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.