Evidence map›Paper›PMID 42374159›Full record

ReviewCommunications biology2026

Lipid droplets as stress-buffering organelles in cancer cell homeostasis.

Ruolun Wei, Claudia K Petritsch

Abstract readReview
In one paragraph

Review in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ruolun WeiStanford University School of Medicine, Stanford, CA, USA.ORCID 0009-0003-6307-9799
Claudia K PetritschStanford University School of Medicine, Stanford, CA, USA. cpetri@stanford.edu.ORCID 0000-0002-3442-4974

Funding

U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R21 NS099836, R01 NS080619, R01 CA164746,CA261717, 17X074
6 · The paper itself

Abstract

Lipid droplets (LDs) are dynamic organelles that support homeostasis and shield cancer cells from stress to promote cancer cell survival, progression, and therapy escape. Here, we summarize recent findings demonstrating LD crosstalk with other organelles and the immune/stromal compartments aimed at buffering metabolic, oxidative, proteotoxic, and lipotoxic stress and stress from cancer treatment and the anti-tumor immune response. We briefly summarize current experimental approaches, including imaging, biochemical, and functional approaches, used to study LD biology. Together, these findings place LDs at the center of cancer cell homeostasis and highlight their emerging potential as translational targets in cancer therapy.

Indexed as

HomeostasisLipid DropletsNeoplasmsStress, PhysiologicalAnimalsHumansOxidative Stress

Identifiers

PMID42374159
PMCPMC13315355

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.