Evidence map›Paper›PMID 42374147›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Novel echocardiographic markers for the assessment of pulmonary hypertension in infants.

Sarah Diamond, Beverly Spray, Amna Qasim, Peter M Mourani, Amit Agarwal, Michael Angtuaco, Ankita Shukla, Richard W Hall, Megha Sharma

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Sarah DiamondDivision of Neonatology, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AK, USA. sediamond@uams.edu.ORCID http://orcid.org/0009-0006-1419-6624
Beverly SprayArkansas Children's Research Institute, Little Rock, AK, USA.
Amna QasimDivision of Cardiology, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AK, USA.
Peter M MouraniDivision of Critical Care, Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-1829-3775
Amit AgarwalDivision of Pulmonology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Michael AngtuacoDivision of Cardiology, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AK, USA.
Ankita ShuklaDivision of Neonatology, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AK, USA.ORCID http://orcid.org/0000-0002-6370-1424
Richard W HallDivision of Neonatology, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AK, USA.ORCID http://orcid.org/0000-0002-3264-3217
Megha SharmaDivision of Neonatology, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AK, USA.ORCID http://orcid.org/0000-0002-9807-1856

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary hypertension (PH) confers significant morbidity and mortality in infants. Risk limits utilization of cardiac catheterization for diagnosis. Pulmonary-artery-acceleration-time (PAAT) and eccentricity-index (EI) are echocardiographically-measured surrogates in adults but data in infants is limited.

objectiveEvaluate the association of PAAT and EI with catheterization-derived hemodynamic measurements in infants without structural heart disease.

methodsThis retrospective review included 30 cardiac catheterization studies performed in infants. Echocardiograms performed within one month of catheterization were reviewed. Multiple linear regression and agreement analyses were conducted between catheterization and echocardiographic data for the presence and severity of PH.

resultsPAAT was significantly associated with mean pulmonary artery pressure (r-square = 0.34, p < 0.003) and pulmonary vascular resistance (r-square = 0.21, p < 0.039). EI was not associated. Agreement of severity of PH by echocardiographic and catheterization data was fair (kappa = 0.29).

conclusionsIn infants, PAAT is associated with invasive hemodynamic measurements, while EI is not associated. These measures do not improve upon other echocardiogram-derived estimates of PH.

Identifiers

PMID42374147

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