Evidence map›Paper›PMID 42374121›Full record

ArticleInternational journal of obesity (2005)2026

Expression of human endogenous retroviruses (HERVs) in the blood of adolescents with and without obesity.

Massimiliano Bergallo, Ivana Rabbone, Cristina Calvi, Anna Pau, Cristina Partenope, Anna Clemente, Simonetta Bellone, Maddalena Dini, Ilaria Galliano, Pier-Angelo Tovo

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Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Massimiliano BergalloUniversity of Turin, Department of Public Health and Pediatric Sciences, Medical School, Turin, Italy.
Ivana RabboneDivision of Paediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Cristina CalviUniversity of Turin, Department of Public Health and Pediatric Sciences, Medical School, Turin, Italy.
Anna PauUniversity of Turin, Department of Public Health and Pediatric Sciences, Medical School, Turin, Italy.
Cristina PartenopeDivision of Paediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Anna ClementeUniversity of Turin, Department of Public Health and Pediatric Sciences, Medical School, Turin, Italy.
Simonetta BelloneDivision of Paediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Maddalena DiniUniversity of Turin, Department of Public Health and Pediatric Sciences, Medical School, Turin, Italy.
Ilaria GallianoUniversity of Turin, Department of Public Health and Pediatric Sciences, Medical School, Turin, Italy. ilaria.galliano@unito.it.ORCID http://orcid.org/0000-0002-1273-3178
Pier-Angelo TovoUniversity of Turin, Department of Public Health and Pediatric Sciences, Medical School, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesHuman endogenous retroviruses (HERVs) are genomic elements derived from ancient retroviral infections and are increasingly recognized for their roles in gene regulation and immune modulation. Obesity is characterized by chronic low-grade inflammation and metabolic dysregulation, which may influence HERV expression. SUBJECTS/

methodsIn this study, we evaluated the transcriptional levels of HERV-H-pol, HERV-K-pol, and HERV-W-pol in peripheral blood from adolescents with obesity as compared to healthy normal weight controls (HC). Total RNA was extracted from whole blood samples, and gene expression was assessed using quantitative reverse-transcription PCR (RT-qPCR), with GAPDH as a reference gene.

resultsHERV-H-pol and HERV-K-pol were significantly upregulated in adolescents with obesity as compared to HC, whereas HERV-W-pol was downregulated. No significant associations were observed between HERV expression levels and age, sex, or metabolic parameters.

conclusionsThese findings suggest that obesity in adolescents is associated with a differential regulation of HERV elements, possibly reflecting the impact of chronic inflammatory and metabolic stress. HERV dysregulation may represent a novel molecular feature of obesity and warrants further investigation as a potential biomarker or contributor to obesity-related complications.

Identifiers

PMID42374121

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