Observational studyScientific reports2026
Association of AQP5 gene variants and mRNA expression with caries severity in a dental practice cohort: a randomized trial.
Observational study in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aquaporin 5 (AQP5) is crucial for salivary secretion, composition and enamel mineralization. Genetic variations in AQP5 may influence susceptibility to dental diseases such as caries. This study investigated the association between AQP5 single nucleotide polymorphisms (SNPs), AQP5 mRNA expression, and caries severity in a dental practice cohort. A total of 246 patients were enrolled. Caries experience was assessed using the decayed, missing, and filled (DMF) index, and salivary AQP5 mRNA expression was quantified by RT-qPCR. Genotyping included rs2878771, rs296763, rs3736309, and rs3759129. Statistical analyses comprised Chi-square testing, ROC analysis with Youden Index determination, and binary logistic regression adjusted for age and sex. The A allele of rs3736309 was associated with an increased risk of severe caries, particularly in patients over 60 years of age. AQP5 mRNA expression was higher in individuals with severe caries and in carriers of the C allele of rs2878771. ROC analysis identified an AQP5 expression cut-off (0.11274) that discriminated between severe and non-severe caries (AUC = 0.578, p = 0.048). Logistic regression confirmed AQP5 expression as an independent predictor of severe caries (p = 0.005). AQP5 expression and genetic variation appear to contribute to caries susceptibility in an age-dependent manner with moderate effects. The intronic variant rs3736309 was associated with caries severity. The biological mechanisms underlying this association remain unclear and require functional investigation. These findings support a potential role of AQP5 as an exploratory biomarker candidate for caries risk, particularly in elderly individuals.Trial registration: German Clinical Trial Registry No. DRKS00032425, date of registration: 2023-08-16.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.