Evidence map›Paper›PMID 42373991›Full record

ArticleApplied microbiology and biotechnology2026

Effects of controlled fermentation by Lactiplantibacillus plantarum PBS067 on Vitis vinifera L. leaf extract.

Marta Armari, Federica Cascella, Aurora Tritto, Farah Hamed, Shwetha Bangalore Renukaprasad, Ana Moreno Villena, Giuseppe Meca De Caro, Carlos Luz Mínguez, Cesar Francisco Trejo, Barbara Azzimonti

Abstract read
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In one paragraph

Article in Applied microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marta ArmariDepartment of Health Sciences, School of Medicine, Università del Piemonte Orientale, 28100, Novara, Italy.ORCID http://orcid.org/0009-0000-1243-1615
Federica CascellaDepartment of Health Sciences, School of Medicine, Università del Piemonte Orientale, 28100, Novara, Italy.ORCID http://orcid.org/0009-0000-8886-0475
Aurora TrittoRoelmi HPC Srl, Via Celeste Milani 24/26, 21040, Origgio, Varese, Italy.ORCID http://orcid.org/0009-0001-6242-8876
Farah Hamed *Department of Health Sciences, School of Medicine, Università del Piemonte Orientale, 28100, Novara, Italy.ORCID http://orcid.org/0009-0000-9173-3194
Shwetha Bangalore Renukaprasad *Department of Health Sciences, School of Medicine, Università del Piemonte Orientale, 28100, Novara, Italy.ORCID http://orcid.org/0009-0004-5507-7643
Ana Moreno VillenaLaboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés S/N, 46100, Burjassot, Spain.ORCID http://orcid.org/0000-0002-0456-4634
Giuseppe Meca De CaroLaboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés S/N, 46100, Burjassot, Spain.ORCID http://orcid.org/0000-0002-8067-0009
Carlos Luz MínguezLaboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés S/N, 46100, Burjassot, Spain.ORCID http://orcid.org/0000-0002-6922-3064
Cesar Francisco TrejoRoelmi HPC Srl, Via Celeste Milani 24/26, 21040, Origgio, Varese, Italy.ORCID http://orcid.org/0009-0000-4432-3985
Barbara AzzimontiDepartment of Health Sciences, School of Medicine, Università del Piemonte Orientale, 28100, Novara, Italy. barbara.azzimonti@uniupo.it.ORCID http://orcid.org/0000-0001-6364-6595

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitis vinifera L. leaves represent one of the most phenolic-rich grapevine biomasses, exhibiting a broad spectrum of biological activities, including prebiotic and microbiota-modulating ones. However, as they are mainly regarded as agro-industrial waste, they are still an underexploited resource. Probiotic-driven fermentation may offer a promising strategy to enhance their bioactive potential while addressing this challenge. The aim of this study was to evaluate the effects of the in vitro fermentation of Vitis vinifera L. leaf extract (VVLE) by Lactiplantibacillus plantarum PBS067 in terms of phenolic content, antioxidant activity, lactic acid and protein content, and metabolomic profile. Our analysis shows the prebiotic activity of VVLE, as VVLE-supplemented medium allowed probiotic growth without toxic effects. Leaves fermentation led to a significant enrichment in lactic acid and the biotransformation of complex plant-secondary metabolites into smaller derivatives. However, VVLE antioxidant capacity slightly decreased after the fermentation, likely due to the phenolic conversion itself. These results highlight how controlled lacto-fermentation valorizes grapevine leaves, transforming them into sustainable upcycled bioactive products with potential applications within cosmetics, pharmaceuticals, nutraceuticals and complementary medical product sectors. KEY POINTS: • L. plantarum PBS067 thrives in medium supplemented with polyphenol-rich leaf extract • L. plantarum PBS067-driven fermentation modulates VVLE phytochemical profile • L. plantarum PBS067-driven fermentation valorizes viticulture by-products.

Indexed as

FermentationLactiplantibacillus plantarumPlant ExtractsPlant LeavesVitisAntioxidantsLactic AcidPhenolsProbioticsAntioxidantsLactic AcidPhenolsPlant ExtractsLactiplantibacillus plantarum PBS067Probiotic-driven fermentationVitis vinifera L. leavesWaste valorization

Identifiers

PMID42373991
PMCPMC13578193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.