Evidence map›Paper›PMID 42373924›Full record

ArticleCommunications chemistry2026

Machine-learning-assisted continuous flow synthesis of clonidine.

Cloudius R Sagandira, Sinazo Nqeketo, Alexander Pomberger, Daniel Wigh, Christophe Len

Abstract read
In one paragraph

Article in Communications chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cloudius R SagandiraPharmaceutical Technologies, Council for Scientific and Industrial Research (CSIR), Pretoria, South Africa. csagandira@csir.co.za.ORCID http://orcid.org/0000-0002-6485-3606
Sinazo NqeketoPharmaceutical Technologies, Council for Scientific and Industrial Research (CSIR), Pretoria, South Africa.ORCID http://orcid.org/0000-0002-2263-5248
Alexander PombergerReactWise Technologies Ltd, London, UK.
Daniel WighReactWise Technologies Ltd, London, UK.ORCID http://orcid.org/0000-0002-0494-643X
Christophe LenInstitute of Chemistry for Life and Health Sciences, Chimie ParisTech, CNRS, PSL Research University, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clonidine•HCl is a clinically important imidazoline derivative whose manufacturing routes have seen little innovation since their development in the mid-to-late 20

Identifiers

PMID42373924
PMCPMC13683395

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.