Evidence map›Paper›PMID 42373814›Full record

ReviewPlant cell reports2026

Diverse molecular mechanisms of in vivo haploid induction in plants: from fertilization interference to genome programming.

Wenjun Wu, Yueshi Ding, Yuhong Guan, Zhu Luo, Xiang Liu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Plant cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenjun Wu *School of Urban Construction and Ecological Technology, Shanghai Institute of Technology, 100 Haiquan Road, Fengxian District, Shanghai, 202418, China.
Yueshi Ding *School of Urban Construction and Ecological Technology, Shanghai Institute of Technology, 100 Haiquan Road, Fengxian District, Shanghai, 202418, China.
Yuhong GuanSchool of Urban Construction and Ecological Technology, Shanghai Institute of Technology, 100 Haiquan Road, Fengxian District, Shanghai, 202418, China.
Zhu LuoSchool of Urban Construction and Ecological Technology, Shanghai Institute of Technology, 100 Haiquan Road, Fengxian District, Shanghai, 202418, China.
Xiang LiuSchool of Urban Construction and Ecological Technology, Shanghai Institute of Technology, 100 Haiquan Road, Fengxian District, Shanghai, 202418, China. liuxiang@sit.edu.cn.

Funding

Key project at central government level: The ability establishment of sustainable use for valuable Chinese medicine resources 2060302
6 · The paper itself

Abstract

In vivo haploid induction has revolutionized crop breeding by shifting it from experience-driven selection to precision design methodologies. This review synthesizes three core mechanistic modules-male gamete defects (MTL/DMP/KPL), gametophyte reprogramming (BBM-BAR1), and centromere engineering (CENH3/KNL2)-into a cohesive framework and provides a critical assessment of their respective constraints. We emphasize emerging technological platforms (HIEdit, GEDH) that support transgene-free genome editing and outline advances in synthetic apomixis aimed at stabilizing hybrid vigor. Defining innovations include temperature-sensitive enhancement, synergistic mutation pyramiding, and AI-aided rational design. Persistent challenges include low efficiency in dicots, large-genome crops, and paternal haploid induction. Future research should integrate multiomics, synthetic biology, and machine learning to develop universal, cross-species haploid induction systems.

Indexed as

FertilizationGenome, PlantHaploidyPlantsCentromereGene EditingPlant BreedingCentromere engineeringCRISPR/Cas9Doubled haploidHaploid inductionMolecular mechanismsSynthetic apomixis

Identifiers

PMID42373814

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.