ArticleNucleic acids research2026
Epigenetic landscape of synthetic human centromere core regions: CENP-A assembly and euchromatic modifications interdependently antagonize heterochromatin accumulation.
Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Centromeres are specialized chromatin structures essential for equal chromosome segregation. The human centromeres are organized on a portion of homogeneously repeated DNA sequence and contains nucleosomes including centromere specific histone H3 variant CENP-A. Histone modifications around the CENP-A dense region are also thought to have important roles in centromere function. Here, we used human artificial chromosome (HAC) system based on synthetic centromeric repeat DNA to enable structural and chromatin analysis at ∼2-kb resolution within defined centromere core domains. Analysis using this HAC centromere showed that the CENP-A dense regions span approximately 18-50 kb in size and coexisted with euchromatic histone modifications in an interdependent manner. We further found that when DNA replication reduced CENP-A density, a heterochromatin modification H3K9me3 transiently accumulated in the CENP-A-dense regions. This accumulation was suppressed by the CENP-A deposition factor HJURP and the histone acetyltransferase KAT7, suggesting that CENP-A assembly and euchromatic modifications interdependently antagonize heterochromatin accumulation. The synthetic centromere DNA generated in this study elucidates the epigenetic landscape within the centromere core regions and provides a more precise framework for understanding the dynamic balance between CENP-A assembly and histone modifications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.