Evidence map›Paper›PMID 42373669›Full record

ArticleNature communications2026

Impaired IFNγ responsiveness of monocyte-derived lung cells limits immunity to Mycobacterium tuberculosis.

Weihao Zheng, Jason D Limberis, Zachary P Howard, Alexander Mohapatra, Enzo Takagi, Joel D Ernst

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. CD4Frontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Weihao ZhengDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, California, USA. weihao.zheng@ucsf.edu.ORCID http://orcid.org/0000-0002-8038-1207
Jason D LimberisDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, California, USA.ORCID http://orcid.org/0000-0002-7893-8416
Zachary P HowardDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, California, USA.
Alexander MohapatraDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, California, USA.ORCID http://orcid.org/0000-0003-0400-6146
Enzo TakagiDivision of Nephrology, Department of Medicine, University of California, San Francisco, California, USA.ORCID http://orcid.org/0000-0002-2625-686X
Joel D ErnstDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, California, USA. joel.ernst@ucsf.edu.ORCID http://orcid.org/0000-0001-9951-6207

Funding

MUTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007185 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David J Erle, LAURENCE HUANG · 1985 to 2026
$24.6M
Initiation of the Immune Response to M. tuberculosisR01AI051242 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ERNST, JOEL D. · 2002 to 2019
$8.3M
UCSF-UCB Tuberculosis Research Advancement Center (TRAC)P30AI168440 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PAYAM NAHID · 2022 to 2026
$5.8M
Functional dynamics of TB granuloma architecture - Diversity Supplement for Kelley J. MartinezU01AI166309 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joel D. Ernst · 2022 to 2026
$3.2M
Tuberculosis Research and Mentorship Program (TB RAMP II)R25AI147375 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Elizabeth Fair, PAYAM NAHID · 2020 to 2026
$2.8M
Mechanistic investigation of differential T cell responses to distinct Mycobacterium tuberculosis antigensF31AI172360 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOWARD, ZACHARY · 2022 to 2024
$132k
Impact of Mycobacterium tuberculosis on monocyte differentiation in vivoF32HL162424 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOHAPATRA, ALEXANDER · 2023 to 2023
$81k
NHLBI NIH HHS F32 HL162424NHLBI NIH HHS T32 HL007185NIAID NIH HHS F31 AI172360NIAID NIH HHS P30 AI168440NIAID NIH HHS R01 AI051242NIAID NIH HHS R25 AI147375NIAID NIH HHS U01 AI166309U.S. Department of Health & Human Services | National Institutes of Health (NIH) F31 AI172360U.S. Department of Health & Human Services | National Institutes of Health (NIH) F32 HL162424U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30 AI168440U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01 AI051242U.S. Department of Health & Human Services | National Institutes of Health (NIH) R25 AI147375U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32 HL007185U.S. Department of Health & Human Services | National Institutes of Health (NIH) U01 AI166309
6 · The paper itself

Abstract

Lung mononuclear phagocyte subsets differ in their ability to restrict Mycobacterium tuberculosis (Mtb) during chronic infection, yet the mechanisms underlying this difference are not well defined. Here, we show that CD11c

Indexed as

Interferon-gammaLungMonocytesMycobacterium tuberculosisAnimalsCD11c AntigenCD4-Positive T-LymphocytesFemaleMacrophages, AlveolarMiceMice, Inbred C57BLSignal TransductionCD11c AntigenInterferon-gamma

Identifiers

PMID42373669
PMCPMC13458731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.