Evidence map›Paper›PMID 42373625›Full record

ArticleNature communications2026

Hundreds of cardiac MRI traits derived using 3D diffusion autoencoders share a common genetic architecture.

Sara Ometto, Soumick Chatterjee, Andrea Mario Vergani, Arianna Landini, Sodbo Sharapov, Edoardo Giacopuzzi, Alessia Visconti, Emanuele Bianchi, Federica Santonastaso, Emanuel M Soda and 6 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sara Ometto *Human Technopole, Milan, Italy.ORCID http://orcid.org/0009-0009-1960-5062
Soumick Chatterjee *Human Technopole, Milan, Italy.ORCID http://orcid.org/0000-0001-7594-1188
Andrea Mario VerganiHuman Technopole, Milan, Italy.ORCID http://orcid.org/0000-0003-3378-4406
Arianna LandiniHuman Technopole, Milan, Italy.ORCID http://orcid.org/0000-0001-8698-727X
Sodbo SharapovHuman Technopole, Milan, Italy.
Edoardo GiacopuzziHuman Technopole, Milan, Italy.ORCID http://orcid.org/0000-0002-5692-366X
Alessia ViscontiHuman Technopole, Milan, Italy.ORCID http://orcid.org/0000-0003-4144-2019
Emanuele BianchiHuman Technopole, Milan, Italy.ORCID http://orcid.org/0009-0003-8673-8937
Federica SantonastasoHuman Technopole, Milan, Italy.
Emanuel M SodaHuman Technopole, Milan, Italy.
Francesco CisterninoHuman Technopole, Milan, Italy.ORCID http://orcid.org/0000-0001-9024-062X
Carlo Andrea PivatoDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.ORCID http://orcid.org/0000-0001-5195-8815
Francesca IevaHuman Technopole, Milan, Italy.
Emanuele Di AngelantonioHuman Technopole, Milan, Italy.
Nicola PirastuHuman Technopole, Milan, Italy.ORCID http://orcid.org/0000-0002-5363-3886
Craig A GlastonburyHuman Technopole, Milan, Italy. craig.glastonbury@fht.org.ORCID http://orcid.org/0000-0001-5542-2225

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biobank-scale imaging provides an unprecedented opportunity to characterise how thousands of organ phenotypes vary in populations. However, deriving specific phenotypes from imaging data requires time-consuming expert annotation, limiting scalability. In this study, we develop a 3D diffusion autoencoder to derive latent phenotypes from temporally resolved cardiac MRI data of 71,017 UK Biobank participants. These phenotypes are reproducible, heritable (h

Indexed as

HeartMagnetic Resonance ImagingAutoencoderFemaleGenome-Wide Association StudyHumansImaging, Three-DimensionalMalePhenotypePolymorphism, Single NucleotideUK Biobank

Identifiers

PMID42373625
PMCPMC13482823

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.