Cobalt-catalyzed asymmetric three-component reductive addition of alkynes with alkyl halides and imines.

Liting Hou, Wenwen Wu, Zihan Wang, Xianqing Wu, Jingping Qu, Yifeng Chen

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Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Liting Hou *Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.

Wenwen Wu *Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.

Zihan WangKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.

Xianqing WuKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China. xianqingwu@ecust.edu.cn.ORCID http://orcid.org/0000-0003-1757-0635

Jingping QuKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.ORCID http://orcid.org/0000-0002-7576-0798

Yifeng ChenKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China. yifengchen@ecust.edu.cn.ORCID http://orcid.org/0000-0003-3239-6209

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The catalytic dicarbofunctionalization of alkynes is a highly efficient strategy for the rapid assembly of complex, multi-substituted acyclic alkenes from simple feedstocks. Despite significant progress having been made in various racemic transformations, the direct enantioselective construction of multi-substituted acyclic alkenes bearing sterically congested tetrasubstituted stereocenters via multicomponent radical pathways remains a formidable and unsolved challenge in organic chemistry. Herein, we report a cobalt-catalyzed asymmetric three-component radical addition of terminal alkynes, ketimines, and unactivated alkyl iodides, which efficiently delivers polysubstituted allylamine derivatives featuring challenging tetrasubstituted stereocenters. This enantioselective addition protocol proceeds under mild reductive conditions and exhibits broad substrate scope with high functional group tolerance, delivering products with excellent stereoselectivity. Preliminary mechanistic investigations suggest a radical-based cascade process involving stereospecific alkyl radical addition to the alkyne followed by stereoselective addition to the ketimine. This work provides a straightforward and modular strategy to access highly functionalized chiral allylic amines from readily available starting materials.

Identifiers

PMID42373611

DOI10.1038/s41467-026-74433-x

PMCPMC13457599

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LicenceCC BY-NC-ND

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