ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionPositron emission tomography (PET) is a valuable tool for assessing tau pathology in Alzheimer's disease (AD), but it is not widely accessible. Clarifying the relationship between fluid tau species and tau PET in AD may allow for the identification of fluid biomarkers that could serve as more accessible surrogates for tau PET.
methodsCerebrospinal fluid (CSF) and plasma tau species levels were assessed across prodromal to moderate AD subjects (CSF: n = 53, plasma: n = 181) via immunoassays and liquid chromatography-mass spectrometry. Fluid measures were correlated with [
resultsCSF C2N-eMTBR-tau243, tau phosphorylated at threonine 205 (p-tau205), p-tau217, and a peptide from the tau-441 microtubule-binding region (MTBR) (MTBR/243-254) exhibited the highest correlations with [ DISCUSSION: CSF C2N-eMTBR-tau243, MTBR/243-254, p-tau205, and p-tau217 demonstrated comparable strong correlations with tau PET. These findings may guide future development of plasma biomarker surrogates for tau PET.
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