Nickel-Catalyzed 8-Endo Cyclization/Carbonylation for the Synthesis of Eight-Membered Lactams.

Yibin He, Zilin Huang, Yuting Jiang, Hucheng Ma, Xinxin Qi, Xiao-Feng Wu

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Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Yibin HeSchool of Chemistry and Chemical Engineering, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, People's Republic of China.

Zilin HuangSchool of Chemistry and Chemical Engineering, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, People's Republic of China.

Yuting JiangSchool of Chemistry and Chemical Engineering, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, People's Republic of China.

Hucheng MaSchool of Chemistry and Chemical Engineering, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, People's Republic of China.

Xinxin QiSchool of Chemistry and Chemical Engineering, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, People's Republic of China.

Xiao-Feng WuDalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023, Dalian, Liaoning, People's Republic of China.ORCID 0000-0001-6622-3328

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medium-sized lactams are prevalent motifs in many bioactive molecules and natural products. However, their construction remains challenging due to unfavorable enthalpic and entropic barriers during the transition state. Herein, a novel nickel-catalyzed 8-endo cyclization/carbonylation has been achieved for the synthesis of eight-membered lactams bearing a gem-difluoro group. This approach features high regioselectivity, good functional group tolerance, and CO gas-free operation, which provides a good supplement for the preparation of eight-membered lactams via a nickel-catalyzed carbonylation process.

Identifiers

PMID42373569

DOI10.1021/acs.orglett.6c02643

PMCPMC13366684

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