ArticleCancer genomics & proteomics
Integrative Genomic and Clinical Profiling of Colorectal Cancer Liver Metastases to Guide Personalized Surgery and Liver Transplantation.
Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
aimColorectal cancer liver metastases (CRLM) remain a leading cause of cancer-related mortality. Although hepatic resection is the only established curative option, recurrence exceeds 60%, underscoring substantial biologic heterogeneity. Liver transplantation (LT) has re-emerged for highly selected patients with unresectable CRLM, but optimal biologic selection criteria remain undefined. This study integrates genomic and clinical data to develop a biologically grounded framework for surgical and transplant decision-making. MATERIALS AND
methodsThe Memorial Sloan Kettering 2017 metastatic colorectal cancer cohort was analyzed using cBioPortal-formatted clinical, genomic, and survival data. The study included patients with liver-only metastatic presentation. Genomic variables comprised
resultsAmong 503 patients, molecular-risk groups demonstrated distinct survival (5-year OS: 74.5%, 56.6%, and 49.8%;
conclusionMolecular-risk stratification and integrated modeling identify clinically meaningful prognostic groups in CRLM. These findings support incorporation of genomic profiling into precision surgical and transplant evaluation, while emphasizing the need for prospective validation.
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