Phospholipase Cβ regulates negative associative memory through calcium dependent and independent mechanisms.

Pingjin Chu, Madison Rennie, Suzanne Scarlata

Abstract read

In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Pingjin ChuDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.

Madison RennieDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.

Suzanne ScarlataDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts, USA. Electronic address: sfscarlata@wpi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Gαq/PLCβ signaling plays a key role in learning and memory. In mice, the loss of PLCβ1 results in inappropriate responses to adverse events that is directly tied to the ability of PLCβ to mediate calcium signals. Besides this calcium-mobilizing function, PLCβ1 has been shown to have a cytosolic, activity-independent function that keeps stress granules disassembled until stimulation and mediates the nuclear localization of the transcription factor Early Growth Response -1 (EGR-1). Here, we assessed the impact of PLCβ on memory formation in the nematode, Caenorhabditis elegans, whose Gαq/PLCβ signaling system is analogous to mammalian systems. Wild-type N2 worms and egl-8

Indexed as

Caenorhabditis elegansCalciumMemoryPhospholipase C betaAnimalsCaenorhabditis elegans ProteinsEarly Growth Response Protein 1Caenorhabditis elegans ProteinsCalciumEarly Growth Response Protein 1Phospholipase C betacalcium signalingC. elegansCREBEarly growth response protein-1 (EGR-1)learningmemoryPhospholipase Cβ

Identifiers

PMID42372916

DOI10.1016/j.jbc.2026.113308

PMCPMC13427652

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.