Evidence map›Paper›PMID 42372158›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Thick filament molecular interfaces play a critical role in the pathogenesis of hypertrophic cardiomyopathy.

Debabrata Dutta, Yuri Kim, Carolyn Y Ho, Jonathan G Seidman, Christine E Seidman, Roger Craig, Raúl Padrón

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Debabrata DuttaDivision of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655.
Yuri KimCardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115.ORCID 0000-0001-5978-5779
Carolyn Y HoCardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115.ORCID 0000-0002-7334-7924
Jonathan G SeidmanDepartment of Genetics, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-9082-3566
Christine E SeidmanCardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115.ORCID 0000-0001-6380-1209
Roger CraigDivision of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655.ORCID 0000-0002-9707-5409
Raúl PadrónDivision of Cell Biology and Imaging, Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655.ORCID 0000-0002-1412-2450

Funding

Structural basis of the super-relaxed state in human cardiac muscleR01HL164560 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PADRON, RAUL · 2022 to 2025
$2.8M
Dissecting the structural origin of relaxation in skeletal muscleR01AR081941 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Raul Padron · 2023 to 2026
$2.2M
Development of strategies to enhance titin (TTN) expression and treat dilated cardiomyopathy caused by TTN haploinsufficiencyK08HL164885 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Yuri Kim · 2023 to 2026
$676k
British Heart Foundation (BHF) BBC/F/21/220106HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL164560HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K08HL164885HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) AR081941NHLBI NIH HHS K08 HL164885NHLBI NIH HHS R01 HL164560NIAMS NIH HHS R01 AR081941NSF EEC-1647837NSF (NSF) Engineering Research Center on Cellular Metamaterials EEC-1647837The British Heart Foundation's Big Beat Challenge award to CureHeart BBC/F/21/220106
6 · The paper itself

Abstract

Hypertrophic cardiomyopathy (HCM) variants in genes encoding the myosin heavy chain (MHC) (

Indexed as

Cardiomyopathy, HypertrophicCarrier ProteinsMyosin Heavy ChainsMyosin Light ChainsCardiac MyosinsCryoelectron MicroscopyHumansModels, MolecularMutation, MissenseMyosin Binding Protein CCardiac MyosinsCarrier ProteinsMYH7 protein, humanMyosin Binding Protein CMyosin Heavy ChainsMyosin Light Chainscardiac musclehypertrophic cardiomyopathyinteracting-heads motifthick filament

Identifiers

PMID42372158
PMCPMC13342902

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.