Evidence map›Paper›PMID 42371970›Full record

ArticleJournal of the American Chemical Society2026

Unified Access to Biaryl-Bridged Linkages Unlocks Structural Diversification of Noncanonical Cyclic Peptides.

Longhui Yu, Jie Zhang, Xinwei Zhang, Xilun Wu, Ruoyu Liu, Chak Hin Au, Hiroshige Ogawa, Rongbiao Tong, Hugh Nakamura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Longhui YuDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, 999077 Kowloon, Hong Kong SAR, China.
Jie ZhangDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, 999077 Kowloon, Hong Kong SAR, China.
Xinwei ZhangDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, 999077 Kowloon, Hong Kong SAR, China.
Xilun WuDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, 999077 Kowloon, Hong Kong SAR, China.
Ruoyu LiuDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, 999077 Kowloon, Hong Kong SAR, China.
Chak Hin AuDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, 999077 Kowloon, Hong Kong SAR, China.
Hiroshige OgawaDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, 999077 Kowloon, Hong Kong SAR, China.
Rongbiao TongDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, 999077 Kowloon, Hong Kong SAR, China.ORCID 0000-0002-2740-5222
Hugh NakamuraDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, 999077 Kowloon, Hong Kong SAR, China.ORCID 0000-0001-5475-7883

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among ribosomally synthesized and post-translationally modified peptides (RiPPs), there exist cyclic peptides featuring rigid and highly linear biaryl linkages. These biaryl cyclic peptides often exhibit unique structural characteristics absent in conventional cyclic peptides, and many display valuable biological activities. Nevertheless, the supply of such biaryl-bridged cyclic peptides and their analogs has been constrained by their intrinsic rigidity. In this study, we report a systematic and comprehensive synthetic strategy for incorporating ten distinct natural and artificial biaryl/triaryl linkages into arbitrary peptide linkers, inspired by RiPP architectures. This unified synthetic platform, which combines electrochemical decarboxylative C-C bond formation with Larock macrocyclization, enables (i) systematic access to RiPP derivatives from readily available building blocks and (ii) facile preparation of fluorine-containing RiPPs, which are of particular importance in medicinal chemistry, as well as biaryl-bridged cyclic peptides spanning diverse ring sizes. In addition, several of the cihunamide analogs synthesized in this study exhibited antibacterial activity.

Indexed as

Anti-Bacterial AgentsPeptides, CyclicCyclizationMolecular StructureAnti-Bacterial AgentsPeptides, Cyclic

Identifiers

PMID42371970
PMCPMC13383641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.