Observational studyCerebrovascular diseases extra2026
Rates, Risks, and Routes to Reduce Vascular Dementia: A UK-Wide Multicentre Prospective Observational Cohort Study of Cognition after Stroke - Baseline Data and Statistical Analysis Plan (ISRCTN18274006).
Observational study in Cerebrovascular diseases extra, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionStroke is often followed by vascular cognitive impairment and vascular dementia, the most feared complications of stroke. However, understanding of post-stroke cognitive impairment remains limited.
methodsRates, risks, and routes to reduce vascular dementia is an observational cohort study of post-stroke cognition. Patients with haemorrhagic or ischaemic stroke, or transient ischaemic attack, were recruited within 6 weeks of stroke from hospitals across the UK. Consent was obtained from patients with capacity or from relatives/friends in those without capacity. The primary outcome is dementia rate and its severity at 2 years assessed using a 7-level ordinal cognition outcome. Final dementia rate will be compared in those with mild stroke/TIA (worst NIHSS ≤7) versus severe stroke (NIHSS >7). Secondary outcomes will include cognitive impairment, function, mood and quality of life, and predictors of cognitive impairment at 1 and 2 years. Data are shown as number (%), median (interquartile range [IQR]), or mean (standard deviation [SD]).
resultsWe recruited 2,441 patients from 50 hospitals. Of these, 2,432 (99.6%) had a qualifying event of stroke or TIA. The mean age was 68.2 years (SD 13.5), females 979 (40.3%), ethnic minority 170 (7.0%), NIHSS ≤7.1962 (80.7%), onset to recruitment 5 days (IQR 3-13) and diagnosis ICH 192 (7.9%), ischaemic stroke 2,097 (86.2%), TIA 143 (5.9%). The distribution of cognition at baseline (within 6 weeks of onset) was normal 1,300 (53.5%), minor neurocognitive disorder - single domain 351 (14.4%), minor neurocognitive disorder - multi-domain 263 (10.8%), major neurocognitive disorder - mild 387 (15.9%), major neurocognitive disorder - moderate 108 (4.4%), and major neurocognitive disorder - severe 23 (0.1%). Participants with more severe stroke were recruited later (8 [IQR 3-17] vs. 5 [2-11] days, p < 0.001), less likely to have capacity (86.3% vs. 96.8%, p < 0.001) and more likely to have had an intracerebral haemorrhage (12.0% vs. 6.8%, p < 0.001).
conclusionWe provide baseline data with the statistical analysis plan in the supplementary material. The data highlight the substantial under-appreciated cognitive burden of stroke, even in the first few days and weeks after onset.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.