ArticleAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc2026
Electrocardiographic Repolarization Changes Following Orchiectomy: Insights Into QT Interval Prolongation and Clinical Implications.
Article in Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSex steroid hormones influence ventricular repolarization and QT interval duration. Testosterone has been associated with shorter QT intervals, whereas androgen deprivation may prolong repolarization indices. However, the effects of orchiectomy on ECG parameters in humans remain insufficiently characterized.
methodsWe conducted a retrospective analysis of 233 consecutive patients who underwent orchiectomy at our hospital between 2006 and 2021. ECG parameters were compared in 44 patients who had ECG recorded both before and after surgery. Furthermore, the effects of surgery were stratified by unilateral (n = 20) and bilateral orchiectomy (n = 24) groups to assess differential effects.
resultsThe mean age was 59.5 years old. Patients in the unilateral group were significantly younger, taller, and heavier (p < 0.05). Orchiectomy was performed for prostate cancer in 22 patients (50%) and for testicular tumors in 19 patients (43%). No significant differences were observed in QRS width before and after surgery. However, QT and corrected QT (QTc) intervals were significantly prolonged following orchiectomy (QT 383 ± 42 to 403 ± 42 ms, p < 0.01, QTc 416 ± 35 to 433 ± 35 ms, p < 0.001). Post-surgery, there were no significant differences in the QT and QTc interval prolongation between the two groups.
conclusionOrchiectomy was associated with prolongation of QT/QTc intervals, particularly after bilateral orchiectomy. These findings suggest that patients after orchiectomy may be more susceptible to additional factors that prolong ventricular repolarization, including electrolyte abnormalities and QT-prolonging medications. Careful ECG monitoring may be warranted in selected patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.