Evidence map›Paper›PMID 42371569›Full record

ArticleBiochemistry research international2026

Extracellular Vesicles From Young Human Myogenic Progenitor Cells Rejuvenate Aged Cells.

Lorenzo Marramiero, Ester Sara Di Filippo, Federica Di Marco, Piero Del Boccio, Cristian Celia, Luisa Di Marzio, Nicola d'Avanzo, Tiziana Pietrangelo, Stefania Fulle, Rosa Mancinelli

Abstract read
In one paragraph

Article in Biochemistry research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lorenzo MarramieroDept Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University Chieti-Pescara, 66100, Chieti, Italy, unich.it.ORCID https://orcid.org/0009-0002-5420-9814
Ester Sara Di FilippoDept Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University Chieti-Pescara, 66100, Chieti, Italy, unich.it.ORCID https://orcid.org/0000-0001-9531-7788
Federica Di MarcoDept Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University Chieti-Pescara, 66100, Chieti, Italy, unich.it.ORCID https://orcid.org/0000-0002-1281-607X
Piero Del BoccioDept Sciences, "G. D'Annunzio" University Chieti-Pescara, Chieti, 66100, Italy, unich.it.ORCID https://orcid.org/0000-0003-1653-2194
Cristian CeliaDept Pharmacy, "G. D'Annunzio" University Chieti-Pescara, Chieti, 66100, Italy, unich.it.ORCID https://orcid.org/0000-0002-0590-5429
Luisa Di MarzioDept Pharmacy, "G. D'Annunzio" University Chieti-Pescara, Chieti, 66100, Italy, unich.it.ORCID https://orcid.org/0000-0002-2518-7188
Nicola d'AvanzoDepartment of Experimental and Clinical Medicine, "Magna Graecia" University of Catanzaro, Catanzaro, 88100, Italy, unicz.it.ORCID https://orcid.org/0000-0001-6945-6653
Tiziana PietrangeloDept Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University Chieti-Pescara, 66100, Chieti, Italy, unich.it.ORCID https://orcid.org/0000-0002-7507-1255
Stefania FulleDept Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University Chieti-Pescara, 66100, Chieti, Italy, unich.it.ORCID https://orcid.org/0000-0003-4557-9127
Rosa MancinelliDept Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University Chieti-Pescara, 66100, Chieti, Italy, unich.it.ORCID https://orcid.org/0000-0002-1538-7784

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The physiological age-related decline in skeletal muscle mass, power, and function is challenging for humans. Skeletal muscle has been recently recognized as a secretory organ, with human myogenic progenitor cells (hMPCs) releasing extracellular vesicles (EVs). Here, we investigate the role of hMPC-derived EVs as mediators in skeletal muscle aging. This heterologous approach enables the analysis of age-related variations in EV burden and their impact on human muscle stem cell function. Therefore, we isolated EVs from hMPCs obtained from

Indexed as

extracellular vesicleshuman adult myogenic progenitor cellsmicroRNAssenescenceskeletal muscle

Identifiers

PMID42371569
PMCPMC13310389

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.