Evidence map›Paper›PMID 42371557›Full record

ArticleJournal of anesthesia and translational medicine2026

Comparison of functional disability in older surgical patients with and without probable cognitive impairment: A longitudinal prospective cohort study.

Ellene Yan, Yasmin Alhamdah, Nina Butris, Paras Kapoor, Leif Erik Lovblom, Jean Wong, David F Tang-Wai, Linda Mah, Shabbir Mh Alibhai, Maria Carmela Tartaglia and 2 more

Abstract read
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In one paragraph

Article in Journal of anesthesia and translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ellene YanDepartment of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada.
Yasmin AlhamdahDepartment of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada.
Nina ButrisDepartment of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada.
Paras KapoorDepartment of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada.
Leif Erik LovblomBiostatistics Department, University Health Network, Toronto, ON M5G 1X6, Canada.
Jean WongDepartment of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada.
David F Tang-WaiTemerty Faculty of Medicine, University of Toronto, ON M5S 3K3, Canada.
Linda MahTemerty Faculty of Medicine, University of Toronto, ON M5S 3K3, Canada.
Shabbir Mh AlibhaiTemerty Faculty of Medicine, University of Toronto, ON M5S 3K3, Canada.
Maria Carmela TartagliaTemerty Faculty of Medicine, University of Toronto, ON M5S 3K3, Canada.
David HeTemerty Faculty of Medicine, University of Toronto, ON M5S 3K3, Canada.
Frances ChungDepartment of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Understanding the recovery trajectory of functional disability in older adults with cognitive impairment can enhance perioperative care through early identification of at-risk patients, risk stratification, and proactive post-discharge planning. This multicenter longitudinal study compared the prevalence and trajectory of functional disability preoperatively and at 30, 90, and 180 days postoperatively between 307 older non-cardiac surgical participants with and without probable cognitive impairment, and examined their incidence of adverse postoperative outcomes. Methods: Online and telephone assessments were administered to assess cognition and functional disability. Cognition was assessed using the Ascertain Dementia Eight-item Questionnaire (AD8), with a preoperative score ≥2 classifying probable cognitive impairment. Functional disability was self-reported preoperatively and at 30, 90, and 180 days postoperatively using the 12-item World Health Organization Disability Assessment Schedule 2.0, with scores ≥ 16% indicating functional disability exceeding a patient-acceptable symptom state. Results: Of 307 participants, 17% screened positive for probable cognitive impairment using the AD8 preoperatively. Participants with probable cognitive impairment had a significantly higher perioperative prevalence of functional disability than those without. Nevertheless, probable cognitive impairment did not modify the recovery pattern of functional disability. Additionally, probable cognitive impairment was associated with greater postoperative delirium (OR: 7.37 [95% CI 2.25, 25.97], Conclusions: A positive AD8 screen was associated with greater perioperative functional disability and adverse clinical outcomes. Despite this heightened risk, we did not find evidence that probable cognitive impairment modified the recovery trajectory of functional disability. Our exploratory study suggests that the AD8 may be useful in guiding patient-centered preoperative discussions and identifying patients with probable cognitive impairment who may warrant closer perioperative monitoring.

Indexed as

Adverse outcomesCognitive screening toolsFunctional disabilityOlder patientsPerioperative assessment

Identifiers

PMID42371557
PMCPMC13310614

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.