Evidence map›Paper›PMID 42371482›Full record

Trial reportDrug design, development and therapy2026

Granisetron Reduces Norepinephrine Requirement for Preventing Post‑Induction Hypotension in Elderly Patients Undergoing Laparoscopic Gastrointestinal Surgery.

Yanting Zhang, Miaofei Chu, Youfa Zhou, Gang Chen

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yanting Zhang *Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Miaofei Chu *Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Youfa ZhouDepartment of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Gang ChenDepartment of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.ORCID 0000-0003-4262-9491

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Prophylactic antiemetics are routinely used in gastrointestinal surgery. This study investigated whether granisetron pretreatment alters norepinephrine requirements for preventing post-induction hypotension in elderly patients. Methods: In this randomized double-blind trial, 64 patients (60-74 years) undergoing laparoscopic gastrointestinal resection received intravenous granisetron (3 mg) or saline placebo before induction. The 50% effective dose (ED Results: Baseline characteristics were comparable between the two groups. The up-down sequential analysis revealed that the ED Conclusion: Granisetron pretreatment significantly reduces the ED

Indexed as

AntiemeticsDigestive System Surgical ProceduresGranisetronHypotensionLaparoscopyNorepinephrineAgedDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMaleMiddle AgedAntiemeticsGranisetronNorepinephrineED50effective dose 50elderlygranisetronhypotensionlaparoscopic gastrointestinal surgerynorepinephrine

Identifiers

PMID42371482
PMCPMC13310409

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.