ArticleCureus2026
Blood Culture Utilization, Contamination Rates, Antibiotic Use, and Patient Outcomes in Intensive Care Units at a Tertiary Care Hospital in Western India: A Prospective Observational Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Background and objective Bloodstream infections present a severe clinical challenge in intensive care units (ICUs), making timely and accurate blood cultures (BCs) critical for diagnosis. However, pre-analytical errors frequently compromise results and drive unnecessary broad-spectrum antibiotic use. The objective of this study was to describe baseline BC utilization, contamination rates, antimicrobial resistance profiles, and patient outcomes across different ICUs at a tertiary care hospital. Methods A 12-month prospective observational study was conducted at a 1000-bedded tertiary hospital in Surat, India. BC utilization, contamination rates, pathogen profiles, and defined daily doses (DDDs) were analyzed for 1704 cultures. Clinical outcomes were followed for 142 culture-positive patients. Results Overall BC utilization was 62.3 per 1000 patient-days, peaking in the medical ICU (MICU; 107.12). Observed high utilization units also show a high contamination rate, which was highest in the MICU (27%) compared to the neonatal ICU (NICU; 21%) and pediatric ICU (PICU; 19%). Gram-negative bacteria predominated (>79% across wards), with
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