ReviewCureus2026
Adjunctive Autologous Platelet Concentrates for Periodontal Regeneration in Intrabony Defects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal intrabony defects remain a clinical challenge because conventional periodontal therapy may reduce inflammation but does not always restore lost supporting tissues. This systematic review and meta-analysis evaluated whether autologous platelet-concentrate adjuncts improve clinical and radiographic outcomes when used with regenerative periodontal therapy. Ten randomized controlled trials were included, all assessing platelet-rich fibrin or related platelet-concentrate preparations, including concentrated growth factors, injectable platelet-rich fibrin, advanced platelet-rich fibrin, and titanium-prepared platelet-rich fibrin, in the treatment of periodontal intrabony defects. The primary clinical analysis pooled clinical attachment level or relative attachment level gain and showed a significant benefit favoring platelet-concentrate adjunct regeneration (PCA) compared with regenerative therapy without platelet concentrates. A reduced sensitivity analysis also favored the platelet-concentrate group, supporting the consistency of the clinical findings. Radiographic bone-fill or defect-depth reduction outcomes also showed a favorable direction for platelet-concentrate adjuncts, although this analysis demonstrated greater variability across studies and did not reach statistical significance. Overall, the findings suggest that autologous platelet concentrates may provide a modest but clinically relevant adjunctive benefit in periodontal intrabony-defect regeneration, particularly for clinical attachment improvement. However, radiographic outcomes should be interpreted with caution because of differences in imaging methods, grafting materials, platelet-concentrate protocols, and follow-up periods. These results support the use of platelet-concentrate adjuncts as a promising component of regenerative periodontal therapy while emphasizing the need for larger, standardized randomized trials with consistent outcome reporting and longer follow-up.
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Registered trials
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