ReviewApplied biochemistry and biotechnology2026
Enhancing Antimicrobial Efficacy: The Role of Metal Complexation in Chitosan-Based Antimicrobial Agents.
Review in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
Abstract
Chitosan (CTS) is widely recognized for its intrinsic antimicrobial properties. Recent advancements demonstrate that the antimicrobial efficacy of CTS can be significantly enhanced through complexation with various metals such as Cu(II), Zn(II), Ag(I), Co(II), Ni(II), and many other metals. This chelation not only improves the physicochemical stability and solubility of the complexes but also promotes synergistic antimicrobial effects by facilitating controlled release of bioactive metal ions. These metal ions exert bactericidal effects through mechanisms such as generation of reactive oxygen species (ROS), enzyme inactivation, and disruption of microbial metabolism. Consequently, CTS-metal complexes demonstrate superior antibacterial activity compared to pristine CTS or metal ions alone. This review aims to provide a comprehensive overview of CTS-metal complexes focusing on their antimicrobial potential and enhanced activity upon complexation. Understanding the relationship between CTS and metal ions offers valuable insights into designing potent antimicrobial agents that can effectively address the growing challenge of AMR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.