Evidence map›Paper›PMID 42371324›Full record

ArticleAnnals of surgical oncology2026

Correlations Between the Histologic Growth Patterns of Peritoneal and Liver Metastases From Colorectal Cancer.

Noémie Zenaty, Radu Bachmann, Charif Khaled, Pieter Demetter, Francesco Sclafani, Pamela Baldin, Ana Veron Sanchez, Michel Moreau, Vincent Donckier, Gabriel Liberale

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Noémie ZenatyDepartment of Surgical Oncology, Université Libre de Bruxelles (ULB), The Brussels University Hospital (H.U.B), Jules Bordet Institute, Brussels, Belgium.
Radu BachmannDepartment of Surgery, Cliniques Universitaires Saint-Luc (UCLouvain), Brussels, Belgium.
Charif KhaledDepartment of Surgical Oncology, Université Libre de Bruxelles (ULB), The Brussels University Hospital (H.U.B), Jules Bordet Institute, Brussels, Belgium.
Pieter DemetterDepartment of Pathology, Laboratory for Experimental Gastroenterology, Université Libre de Bruxelles, Brussels, Belgium.
Francesco SclafaniDepartment of Gastrointestinal Oncology, Université Libre de Bruxelles (ULB), The Brussels University Hospital (H.U.B), Jules Bordet Institute, Brussels, Belgium.
Pamela BaldinDepartment of Pathology, Cliniques Universitaires Saint-Luc (UCLouvain), Brussels, Belgium.
Ana Veron SanchezDepartment of Radiology, Université Libre de Bruxelles (ULB), The Brussels University Hospital (H.U.B), Jules Bordet Institute, Brussels, Belgium.
Michel MoreauData Centre and Statistics Department, Université Libre de Bruxelles (ULB), The Brussels University Hospital (H.U.B), Jules Bordet Institute, Brussels, Belgium.
Vincent DonckierDepartment of Surgical Oncology, Université Libre de Bruxelles (ULB), The Brussels University Hospital (H.U.B), Jules Bordet Institute, Brussels, Belgium.
Gabriel LiberaleDepartment of Surgical Oncology, Université Libre de Bruxelles (ULB), The Brussels University Hospital (H.U.B), Jules Bordet Institute, Brussels, Belgium. gabriel.liberale@hubruxelles.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHistologic growth patterns (HGPs) of both peritoneal metastasis (PM) and liver metastasis (LM) have emerged as prognostic factors for patients undergoing curative surgery for metastatic colorectal cancer (CRC). The main objectives of the study were, first, to evaluate the correlation between PMHGP and LMHGP of CRC patients who underwent curative-intent cytoreductive surgery (CRS) and LM resection and, second, to assess the prognostic impact of HGP type.

methodsThis retrospective bicentric study included patients treated with both CRS and LM resection for metastatic CRC. Histologic growth patterns were classified as pushing (P-HGP) and infiltrating (I-HGP) for PM, and as desmoplastic HGP (D-HGP) and non-desmoplastic (ND-HGP) for LM. Correlation between PMHGP and LMHGP was assessed using the chi-square test. Overall survival (OS) and disease-free survival (DFS) were evaluated using Kaplan-Meier and Cox regression.

resultsThe study included 44 patients. Of the 44 patients, 9 (20.5%) had P-HGP + D-HGP, 23 (52.3%) had I-HGP + ND-HGP, 5 (11.4%) had P-HGP + ND-HGP, and 7 (15.9%) had I-HGP + D-HGP. Significant correlation was observed between PMHGP and LMHGP (p = 0.0085; Φ = 0.3965). The patients with I-HGP + ND-HGP had shorter OS and DFS than those with other combinations: 34 versus 64 months (HR, 2.067; p = 0.0672) for OS, and 14 versus 25 months (hazard ratio [HR], 1.775; p = 0.1071) for DFS.

conclusionsThis study highlighted a significant correlation between PMHGP and LMHGP in metastatic CRC. However, survival trends were nonsignificant.

Indexed as

Colorectal cancerCytoreductive surgeryHistological growth patternLiver metastasisLiver resectionPeritoneal metastasis

Identifiers

PMID42371324

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