Evidence map›Paper›PMID 42371236›Full record

ArticleMolecular neurobiology2026

Calcium Overloading-Induced UBE2O Upregulation Alleviates Neuronal Apoptosis.

Jiabin Jin, Zhuojia Yang, Ailing Kang, Yinhui Zhao, Zhuofu Cai, Minhao Qiu, Weihong Song, Yili Wu

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jiabin JinOujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, 325000, Zhejiang, China.
Zhuojia YangWenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, Key Laboratory of Alzheimer's Disease of Zhejiang Province, School of Mental Health, Institute of Aging, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Ailing KangOujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, 325000, Zhejiang, China.
Yinhui ZhaoWenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, Key Laboratory of Alzheimer's Disease of Zhejiang Province, School of Mental Health, Institute of Aging, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Zhuofu CaiWenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, Key Laboratory of Alzheimer's Disease of Zhejiang Province, School of Mental Health, Institute of Aging, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Minhao QiuWenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, Key Laboratory of Alzheimer's Disease of Zhejiang Province, School of Mental Health, Institute of Aging, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Weihong SongWenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, Key Laboratory of Alzheimer's Disease of Zhejiang Province, School of Mental Health, Institute of Aging, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. weihong@wmu.edu.cn.
Yili WuWenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, Key Laboratory of Alzheimer's Disease of Zhejiang Province, School of Mental Health, Institute of Aging, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. wuyili@wmu.edu.cn.

Funding

National Natural Science Foundation of China 82271482National Natural Science Foundation of China 82293642Oujiang Laboratory OJQDSP2022013Science and Technology Department of Zhejiang Province 2023ZY1018Science and Technology Department of Zhejiang Province 2026C02A1148
6 · The paper itself

Abstract

Calcium overloading is implicated in the pathogenesis of Alzheimer's Disease (AD) via the activation of calcineurin signaling. Dysregulation of ubiquitin-conjugating enzyme E2 O (UBE2O), an E2-E3 hybrid enzyme, is involved in AD pathogenesis. However, the effect of calcium overloading-mediated calcineurin activation on UBE2O regulation and the role of UBE2O in calcium overloading-induced apoptosis remain elusive. In this study, we aimed to explore the effect of calcium overloading on UBE2O expression and underlying mechanisms, as well as its role in apoptosis. We found that calcium overloading increases the expression of UBE2O in both neuronal and non-neuronal cells, while calcineurin inhibitor alleviates this effect. Moreover, three functional binding sites of MEF2A, a downstream target of calcineurin, are identified within the promoter region of the UBE2O gene. MEF2A facilitates UBE2O promoter activity, as well as its expression at both mRNA and protein levels. Furthermore, increased UBE2O expression attenuates calcium overloading-induced neuronal apoptosis, while reduced UBE2O expression exacerbates calcium overloading-induced neuronal apoptosis. Moreover, neuron-specific overexpression of UBE2O reduced neuronal apoptosis in 5 × FAD mice. This study demonstrated that calcium overloading-induced UBE2O upregulation is mediated by calcineurin-MEF2A signaling pathway, which acts as a protective response to alleviate neuronal apoptosis. It indicates that UBE2O is a potential therapeutic target for neuronal protection in AD.

Indexed as

ApoptosisCalciumNeuronsUbiquitin-Conjugating EnzymesUp-RegulationAnimalsCalcineurinCalcineurin InhibitorsMEF2 Transcription FactorsMicePromoter Regions, GeneticCalcineurinCalcineurin InhibitorsCalciumMEF2 Transcription FactorsUbiquitin-Conjugating EnzymesAlzheimer’s DiseaseCalcineurinCalcium overloadingMEF2ANeuronal apoptosisUBE2O

Identifiers

PMID42371236

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.