Evidence map›Paper›PMID 42371179›Full record

ArticleJournal of computer-aided molecular design2026

Integrated structure-based and fragment-guided design of isonicotinic acid derivatives as potential KDM4A inhibitors: an in silico study.

Kourosh Eslami, Hajar Sirous, Ilaria Cursaro, Leonardo Milioni, Fatemeh Shafiee, Gabriele Carullo, Sandra Gemma, Sina Rajabi, Giuseppe Campiani, Vincenzo Calderone and 1 more

Abstract read
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In one paragraph

Article in Journal of computer-aided molecular design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kourosh EslamiBioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran.
Hajar SirousBioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran. h_sirous@pharm.mui.ac.ir.ORCID 0000-0003-4311-9952
Ilaria CursaroDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.ORCID 0000-0001-7034-3162
Leonardo MilioniDepartment of Medical Biotechnologies, University of Siena, Viale Mario Bracci 16, 53100, Siena, Italy.
Fatemeh ShafieeBioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran.
Gabriele CarulloDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.ORCID 0000-0002-1619-3295
Sandra GemmaDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.ORCID 0000-0002-8313-2417
Sina RajabiBioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran.
Giuseppe CampianiBioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran.ORCID 0000-0001-5295-9529
Vincenzo CalderoneDepartment of Pharmacy, University of Pisa, Via Bonanno 6, I-56126, Pisa, Italy.ORCID 0000-0002-1441-5421
Simone BrogiBioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran. simone.brogi@unipi.it.ORCID 0000-0001-9375-6242

Funding

Bioinformatics Research Center, Isfahan University of Medical Sciences 240375
6 · The paper itself

Abstract

Lysine-specific demethylase 4 A (KDM4A) is an Fe

Indexed as

Drug DesignEnzyme InhibitorsIsonicotinic AcidsJumonji Domain-Containing Histone DemethylasesCatalytic DomainHumansMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity RelationshipEnzyme InhibitorsIsonicotinic AcidsJumonji Domain-Containing Histone DemethylasesKDM4A protein, humanEpigeneticsFragment-based designIsonicotinic acid derivativesKDM4A inhibitorsMM-GBSAMolecular dynamics (MD) simulation

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.