Evidence map›Paper›PMID 42371167›Full record

ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2026

Treatment of the infected total knee replacement combining DAIR with continuous local antibiotic perfusion: a preliminary case report series.

Kohei Motono, Tomoyuki Matsumoto, Keisuke Oe, Masanori Tsubosaka, Naoki Nakano, Jonathan Jonathan, Tomoaki Fukui, Yohei Kumabe, Atsushi Kitagawa, Takao Inokuchi and 4 more

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Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Kohei MotonoDepartment of Orthopaedic Surgery, Kobe University, Kobe, Japan. mmoko0422@gmail.com.
Tomoyuki MatsumotoDepartment of Orthopaedic Surgery, Kobe University, Kobe, Japan. matsun@m4.dion.ne.jp.ORCID https://orcid.org/0000-0003-4587-0029
Keisuke OeDepartment of Orthopaedic Surgery, Kobe University, Kobe, Japan.
Masanori TsubosakaDepartment of Orthopaedic Surgery, Kobe University, Kobe, Japan.
Naoki NakanoDepartment of Orthopaedic Surgery, Kobe University, Kobe, Japan.
Jonathan JonathanDepartment of Orthopaedic Surgery, Kobe University, Kobe, Japan.
Tomoaki FukuiDepartment of Orthopaedic Surgery, Kobe University, Kobe, Japan.
Yohei KumabeDepartment of Orthopaedic Surgery, Kobe University, Kobe, Japan.
Atsushi KitagawaDepartment of Orthopaedic Surgery, Hyogo Rehabilitation Center Hospital, Kobe, Japan.
Takao InokuchiDepartment of Orthopaedic Surgery, Hyogo Prefectural Harima-Himeji General Medical Center, HImeji, Japan.
Akihiro MaruoDepartment of Orthopaedic Surgery, Hyogo Prefectural Harima-Himeji General Medical Center, HImeji, Japan.
Shinya HayashiDepartment of Orthopaedic Surgery, Kobe University, Kobe, Japan.
Hirotsugu MuratsuDepartment of Orthopaedic Surgery, Hyogo Prefectural Harima-Himeji General Medical Center, HImeji, Japan.
Ryosuke KurodaDepartment of Orthopaedic Surgery, Kobe University, Kobe, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundContinuous local antibiotics perfusion (CLAP) involves placing a bone marrow needle and a double-lumen tube in the infected area, through which an antibiotic at an appropriate concentration is continuously administered. CLAP has shown good outcomes in patients with bone and soft tissue infections. However, the use of CLAP for late infection after total knee arthroplasty (TKA) is rarely reported. We addressed the gap in the treatment of prosthetic joint infection (PJI) using intra-joint antibiotics perfusion (iJAP) combined with debridement, antibiotics, and implant retention (DAIR) to treat patients with PJI.

methodsThis case series study included seven patients who received iJAP combined with DAIR for the treatment of late infection. Continuous passive motion (CPM) was administered immediately after surgery. The diagnosis of late infection was based on the Musculoskeletal Infection Society criteria. Clinical outcomes including success rate and range of motion at 2 years after iJAP were investigated.

resultsIn all cases, the infection was eradicated with the implants retained. The success rate of the first iJAP with DAIR was 100%, and the average range of motion was 111.9° at 1 year postoperatively.

conclusionsiJAP for late infection after primary TKA resulted in good outcomes, and the range of motion was similar to that reported in previous studies. CPM use immediately after surgery prevented short-circuiting of perfusion and contributed to a good postoperative motion. iJAP with DAIR may be a useful treatment for late infection after TKA.

Indexed as

Anti-Bacterial AgentsArthroplasty, Replacement, KneeKnee ProsthesisProsthesis-Related InfectionsAgedAged, 80 and overCombined Modality TherapyDebridementFemaleHumansMaleMiddle AgedMotion Therapy, Continuous PassivePerfusionRange of Motion, ArticularTreatment OutcomeAnti-Bacterial AgentsAntibioticsContinuous local antibiotics perfusionDebridementIntra-joint antibiotics perfusionLate infection

Identifiers

PMID42371167

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