Evidence map›Paper›PMID 42371150›Full record

SynthesisChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026

Impact of blood product removal versus temporary cerebrospinal fluid diversion on permanent shunting rates in posthemorrhagic hydrocephalus of prematurity: a comparative meta-analysis.

Kwadwo Darko, Anthony Ayamdooh, Olivia Asiedu, Manasseh Sampana, Clement Jubin, Bernice Limann, Joseline Haizel-Cobbina, Fredrick Dapaah-Siakwan, Mabel Banson

Abstract readMeta-AnalysisSystematic ReviewComparative Study
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In one paragraph

Synthesis in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Kwadwo DarkoDepartment of Neurosurgery, Geisinger, Danville, PA, USA. darkobhp@gmail.com.
Anthony AyamdoohCollege of Health Sciences, University of Ghana Medical School, Accra, Ghana.
Olivia AsieduCollege of Health Sciences, University of Ghana Medical School, Accra, Ghana.
Manasseh SampanaCollege of Health Sciences, University of Ghana Medical School, Accra, Ghana.
Clement JubinCollege of Health Sciences, University of Ghana Medical School, Accra, Ghana.
Bernice LimannDepartment of Neurosurgery, Korle Bu Teaching Hospital, Accra, Ghana.
Joseline Haizel-CobbinaDepartment of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Fredrick Dapaah-SiakwanPediatric Residency Program, Valley Children's Healthcare, Madera, CA, USA.
Mabel BansonDepartment of Neurosurgery, Korle Bu Teaching Hospital, Accra, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIntraventricular hemorrhage (IVH) is a major complication of extreme prematurity and a leading cause of posthemorrhagic hydrocephalus (PHH). Standard surgical treatment with temporary CSF diversion (TCD) for severe IVH often leads to permanent shunting and lifelong complications. This study compares blood product removal (BPR) and TCD only in reducing permanent cerebrospinal fluid (CSF) shunt dependence in preterm infants.

methodsA systematic review and meta-analysis were conducted in accordance with PRISMA guidelines to compare treatment outcomes (permanent CSF shunting, post-intervention CSF-related infections, secondary IVH, and mortality) in patients who underwent BPR versus TCD.

resultsSix studies involving 256 patients (128 patients in each treatment group) met inclusion criteria. Baseline demographics, including gestational age, birth weight, and IVH severity, were comparable between groups. BPR was associated with a lower risk of permanent shunting [RR: 0.67 (95% CI: 0.46-1.00) as compared to TCD (p = 0.047). The mean time to shunting was longer in the BPR group, but the difference was not statistically significant (79.6 vs 47.63 days; p = 0.267). TCD was associated with higher rates of CSF-related infections (26.54% vs 2.40%; p = 0.019) and mortality (19.27% vs 3.47%; p = 0.007).

conclusionBPR was associated with a lower risk of permanent shunting and lower rates of mortality and CSF-related infections compared to TCD. While BPR presents a promising alternative to conventional TCD approaches, further studies are needed to validate these findings.

Indexed as

Cerebral HemorrhageCerebral Intraventricular HemorrhageCerebrospinal Fluid ShuntsHydrocephalusHumansInfant, NewbornInfant, PrematureTreatment OutcomeBlood product removalExternal ventricular drainIntraventricular hemorrhage of prematurityNeuroendoscopic lavagePrematurity

Identifiers

PMID42371150

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.