Evidence map›Paper›PMID 42371144›Full record

ArticlePlanta2026

Oxalic acid-driven redox reprogramming modulates NPR1-mediated defense and disease progression in Brassica-Sclerotinia interactions.

Rakesh Punia, Pavitra Kumari, Sapna, Shubham Saini, Ram Avtar, Manoj Kumar Buswal, Dalip Kumar, Aakash, Neeraj Kumar, Mahavir Bishnoi and 1 more

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Article in Planta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Rakesh PuniaDepartment of Plant Pathology, CCS Haryana Agricultural University, Hisar, Haryana, India.
Pavitra KumariDepartment of Plant Pathology, CCS Haryana Agricultural University, Hisar, Haryana, India.
SapnaDepartment of Plant Pathology, CCS Haryana Agricultural University, Hisar, Haryana, India.
Shubham SainiDepartment of Plant Pathology, CCS Haryana Agricultural University, Hisar, Haryana, India.
Ram AvtarDepartment of Genetics and Plant Breeding, CCS Haryana Agricultural University, Hisar, Haryana, India.
Manoj Kumar BuswalDepartment of Plant Pathology, CCS Haryana Agricultural University, Hisar, Haryana, India.
Dalip KumarDepartment of Genetics and Plant Breeding, CCS Haryana Agricultural University, Hisar, Haryana, India.
AakashDepartment of Plant Pathology, CCS Haryana Agricultural University, Hisar, Haryana, India.
Neeraj KumarDepartment of Genetics and Plant Breeding, CCS Haryana Agricultural University, Hisar, Haryana, India.
Mahavir BishnoiDepartment of Genetics and Plant Breeding, CCS Haryana Agricultural University, Hisar, Haryana, India.
Vinod ChouhanDivison of Plant Pathology, ICAR-Indian Agricultural Research Institute, New Delhi, 110012, India. vinod.chouhan1994@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MAIN

conclusionS. sclerotiorum virulence is mediated by oxalic acid-induced redox imbalance. Resistant Brassica genotypes sustain antioxidant capacity and NPR1-dependent systemic acquired resistance, unlike susceptible genotypes showing transient defense responses. Stem rot caused by Sclerotinia sclerotiorum represents a major constraint to Brassica production, with oxalic acid (OA) acting as a key virulence determinant. This study elucidates the role of OA in modulating disease progression, redox homeostasis, antioxidant defenses, and systemic acquired resistance (SAR) signaling in Brassica genotypes contrasting in resistance. Exogenous application of OA significantly exacerbated lesion expansion and disease severity, particularly in susceptible genotypes, which exhibited rapid symptom development, pronounced chlorophyll degradation, excessive reactive oxygen species (ROS) accumulation, elevated lipid peroxidation, and compromised antioxidant enzyme activities. In contrast, resistant genotypes maintained higher antioxidant capacity and displayed tightly regulated ROS dynamics, indicative of effective redox control. Temporal expression profiling of NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1) revealed distinct cultivar-specific regulatory patterns. Susceptible genotypes showed strong but transient early NPR1 induction (up to 5.26-fold), which was not sustained during disease progression, whereas resistant genotypes exhibited intrinsic and temporally coordinated NPR1 activation (3.37- and 9.84-fold at 7 and 14 days post-inoculation, respectively), largely independent of OA treatment. Late-stage NPR1 induction in susceptible genotypes was delayed and insufficient to restrict pathogen spread. Collectively, these findings demonstrate that OA-mediated disruption of redox homeostasis differentially impacts antioxidant defenses and NPR1-dependent SAR signaling, thereby governing cultivar-specific resistance to S. sclerotiorum in Brassica crops.

Indexed as

AscomycotaBrassicaOxalic AcidPlant DiseasesPlant ProteinsAntioxidantsDisease ResistanceGene Expression Regulation, PlantGenotypeHost-Pathogen InteractionsLipid PeroxidationOxidation-ReductionPlant Systemic Acquired ResistanceReactive Oxygen SpeciesAntioxidantsOxalic AcidPlant ProteinsReactive Oxygen SpeciesAntioxidant enzymesOxalic acidRapeseed-mustardReactive oxygen speciesSclerotinia sclerotiorumStem rotSystemic acquired resistance

Identifiers

PMID42371144

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.